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GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research–an update.

  June 20, 2021
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GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research–an update.

GenAlEx: Genetic Analysis in Excel is a cross-platform package for population genetic analyses that runs within Microsoft Excel. GenAlEx offers analysis of diploid codominant, haploid and binary genetic loci and DNA sequences. Both frequency-based (F-statistics, heterozygosity, HWE, population assignment, relatedness) and distance-based (AMOVA, PCoA, Mantel tests, multivariate spatial autocorrelation) analyses are provided.
New features include calculation of new estimators of population structure: G'(ST), G”(ST), Jost’s D(est) and F'(ST) through AMOVA, Shannon Information analysis, linkage disequilibrium analysis for biallelic data and novel heterogeneity tests for spatial autocorrelation analysis. Export to more than 30 other data formats is provided. Teaching tutorials and expanded step-by-step output options are included. The comprehensive guide has been fully revised.
METHODS
GenAlEx is written in VBA and provided as a Microsoft Excel Add-in (compatible with Excel 2003, 2007, 2010 on PC; Excel 2004, 2011 on Macintosh). GenAlEx, and supporting documentation and tutorials are freely available at: http://biology.anu

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Site-directed mutagenesis by overlap extension using the polymerase chain reaction.

Overlap extension represents a new approach to genetic engineering. Complementary oligodeoxyribonucleotide (oligo) primers and the polymerase chain reaction are used to generate twoDNA fragments having overlapping ends. These fragments are combined in a subsequent ‘fusion’ reaction in which the overlapping ends anneal, allowing the 3′ overlap of each strand to serve as a primer for the 3′ extension of the complementary strand. The resulting fusion product is amplified further by PCR.
Specific alterations in the nucleotide (nt) sequence can be introduced by incorporating nucleotide changes into the overlapping oligo primers. Using this technique of site-directed mutagenesis, three variants of a mouse major histocompatibility complex class-I gene have been generated, cloned and analyzed. Screening of mutant clones revealed at least a 98% efficiency of mutagenesis. All clones sequenced contained the desired mutations, and a low frequency of random substitution estimated to occur at approx. 1 in 4000 nt was detected. This method represents a significant improvement over standard methods of site-directed mutagenesis because it is much faster, simpler and approaches 100% efficiency in the generation of mutant product.

Crystal structure of the nucleosome core particle at 2.8 A resolution.

The X-ray crystal structure of the nucleosome core particle of chromatin shows in atomic detail how the histone protein octamer is assembled and how 146 base pairs of DNA are organized into a superhelix around it. Both histone/histone and histone/DNA interactions depend on the histone fold domains and additional, well ordered structure elements extending from this motif.
Histone amino-terminal tails pass over and between the gyres of the DNA superhelix to contact neighbouring particles. The lack of uniformity between multiple histone/DNA-binding sites causes the DNA to deviate from ideal superhelix geometry.

Base-calling of automated sequencer traces using phred. I. Accuracy assessment.

The availability of massive amounts of DNA sequence information has begun to revolutionize the practice of biology. As a result, current large-scale sequencing output, while impressive, is not adequate to keep pace with growing demand and, in particular, is far short of what will be required to obtain the 3-billion-base human genome sequence by the target date of 2005.
To reach this goal, improved automation will be essential, and it is particularly important that human involvement in sequence data processing be significantly reduced or eliminated. Progress in this respect will require both improved accuracy of the data processing software and reliable accuracy measures to reduce the need for human involvement in error correction and make human review more efficient. Here, we describe one step toward that goal: a base-calling program for automated sequencer traces, phred, with improved accuracy. phred appears to be the first base-calling program to achieve a lower error rate than the ABI software, averaging 40%-50% fewer errors in the data sets examined independent of position in read, machine running conditions, or sequencing chemistry.

The language of covalent histone modifications

Histone proteins and the nucleosomes they form with DNA are the fundamental building blocks of eukaryotic chromatin. A diverse array of post-translational modifications that often occur on tail domains of these proteins has been well documented.
Although the function of these highly conserved modifications has remained elusive, converging biochemical and genetic evidence suggests functions in several chromatin-based processes. We propose that distinct histone modifications, on one or more tails, act sequentially or in combination to form a ‘histone code’ that is, read by other proteins to bring about distinct downstream events.

UCHIME improves sensitivity and speed of chimera detection

BACKGROUND
Chimeric DNA sequences often form during polymerase chain reaction amplification, especially when sequencing single regions (e.g. 16S rRNA or fungal Internal Transcribed Spacer) to assess diversity or compare populations. Undetected chimeras may be misinterpreted as novel species, causing inflated estimates of diversity and spurious inferences of differences between populations. Detection and removal of chimeras is therefore of critical importance in such experiments.
RESULTS
We describe UCHIME, a new program that detects chimeric sequences with two or more segments. UCHIME either uses a database of chimera-free sequences or detects chimeras de novo by exploiting abundance data.
UCHIME has better sensitivity than ChimeraSlayer (previously the most sensitive database method), especially with short, noisy sequences. In testing on artificial bacterial communities with known composition, UCHIME de novo sensitivity is shown to be comparable to Perseus. UCHIME is >100× faster than Perseus and >1000× faster than ChimeraSlayer.
BACKGROUND
robert@drive5.com
BACKGROUND
Source, binaries and data: http://drive5.com/uchime.
BACKGROUND
Supplementary data are available at Bioinformatics online.

Anti-CCR6/CCR6 Antibody
PA1201 100ug/vial
EUR 352.8

Genorise® Chicken TNFa cDNA Clone
GR147001 - Ask for price

Genorise® Chicken IFNg cDNA Clone
GR147002 10 µg
EUR 183.6

CCR6
MO15087 100 ug
EUR 490.8

Genorise® Chicken IL-6 cDNA Clone
GR147003 10 µg
EUR 183.6

Genorise® Chicken IL-4 cDNA Clone
GR147004 10 µg
EUR 183.6

Genorise® Chicken IL-10 cDNA Clone
GR147005 10 µg
EUR 183.6

CCR6 Antibody
1-CSB-PA244343
  • EUR 380.40
  • EUR 292.80
  • 100ul
  • 50ul
Description: A polyclonal antibody against CCR6. Recognizes CCR6 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:5000, IHC:1:50-1:200

CCR6 Antibody
1-CSB-PA004845EA01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against CCR6. Recognizes CCR6 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB; Recommended dilution: WB:1:500-1:2000

CCR6 Antibody
DF10207 200ul
EUR 420

CCR6 siRNA
20-abx910877
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

CCR6 siRNA
20-abx910878
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

CCR6 Antibody
1-CSB-PA943255
  • EUR 380.40
  • EUR 292.80
  • 100ul
  • 50ul
Description: A polyclonal antibody against CCR6. Recognizes CCR6 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:50-1:200

CCR6 antibody
70R-13797 100 ug
EUR 386.4
Description: Affinity purified Rabbit polyclonal CCR6 antibody

CCR6 Antibody
37466-100ul 100ul
EUR 302.4

CCR6 antibody
10R-1071 100 ul
EUR 379.2
Description: Mouse monoclonal CCR6 antibody

CCR6 Antibody
ABD10207 100 ug
EUR 525.6

CCR6 Antibody
R30301 100 ug
EUR 419

Anti-ASFV P72 Antibody | MASF-5A-Clone #10E11
MASF-5A-Clone-10E11 1 mg
EUR 667
Description:

Anti-ASFV P72 Antibody | MASF-5A-Clone #10E11 | Immunology Consultants Laboratory

Host: Mouse

Format: Unconjugated AP

Product Type: Primary Antibody

Antibody Clonality: Monoclonal

Anti-ASFV P72 Antibody | MASF-5A-Clone #10G5
MASF-5A-Clone-10G5 1 mg
EUR 667
Description:

Anti-ASFV P72 Antibody | MASF-5A-Clone #10G5 | Immunology Consultants Laboratory

Host: Mouse

Format: Unconjugated AP

Product Type: Primary Antibody

Antibody Clonality: Monoclonal

Genorise® Human GLUT1 cDNA Clone, 10 ug
GR154002 10 µg
EUR 183.6

Genorise® Human cTnT cDNA Clone, 10 ug
GR154003 10 µg
EUR 183.6

Genorise® Human TNN3 cDNA Clone, 10 ug
GR154004 10 µg
EUR 183.6

Genorise® Human BNP cDNA Clone, 10 ug
GR154005 10 µg
EUR 183.6

Genorise® Human Myoglobin cDNA Clone, 10 ug
GR154006 10 µg
EUR 183.6

Genorise® Human ANP cDNA Clone, 10 ug
GR154008 10 µg
EUR 183.6

Genorise® Human Myeloperoxidase cDNA Clone, 10 ug
GR154009 10 µg
EUR 183.6

Genorise® Human GPBB cDNA Clone, 10 ug
GR154010 10 µg
EUR 183.6

Genorise® Human CRP cDNA Clone, 10 ug
GR154011 10 µg
EUR 183.6

Genorise® Human MyBPC3 cDNA Clone, 10 ug
GR154012 10 µg
EUR 183.6

Anti-Avian Leukosis Virus Antibody | MALV-30A-Clone#3B11
MALV-30A-Clone-3B11 1.0 mg
EUR 448
Description:

Anti-Avian Leukosis Virus Antibody | MALV-30A-Clone#3B11 | Immunology Consultants Laboratory

Host: Mouse

Format: Unconjugated AP

Product Type: Primary Antibody

Antibody Clonality: Monoclonal

Anti-Avian Leukosis Virus Antibody | MALV-30A-Clone#5A4
MALV-30A-Clone-5A4 1.0 mg
EUR 448
Description:

Anti-Avian Leukosis Virus Antibody | MALV-30A-Clone#5A4 | Immunology Consultants Laboratory

Host: Mouse

Format: Unconjugated AP

Product Type: Primary Antibody

Antibody Clonality: Monoclonal

Anti-Avian Leukosis Virus Antibody | MALV-30A-Clone#6C2
MALV-30A-Clone-6C2 1.0 mg
EUR 448
Description:

Anti-Avian Leukosis Virus Antibody | MALV-30A-Clone#6C2 | Immunology Consultants Laboratory

Host: Mouse

Format: Unconjugated AP

Product Type: Primary Antibody

Antibody Clonality: Monoclonal

Anti-Avian Leukosis Virus Antibody | MALV-30A-Clone#6D7
MALV-30A-Clone-6D7 1.0 mg
EUR 448
Description:

Anti-Avian Leukosis Virus Antibody | MALV-30A-Clone#6D7 | Immunology Consultants Laboratory

Host: Mouse

Format: Unconjugated AP

Product Type: Primary Antibody

Antibody Clonality: Monoclonal

Genorise® Sheep IL-6 cDNA Clone, 10 ug
GR151001 10 µg
EUR 183.6

Genorise® Ovine IL-2 cDNA Clone, 10 ug
GR151002 10 µg
EUR 183.6

Genorise® Ovine IL-4 cDNA Clone, 10 ug
GR151003 10 µg
EUR 183.6

Genorise® Bovine IL-1b cDNA Clone, 10 ug
GR152001 10 µg
EUR 183.6

Genorise® Rabbit IL-1b cDNA Clone, 10 ug
GR153001 10 µg
EUR 183.6

Genorise® Human H-FABP cDNA Clone, 10 ug
GR154001 10 µg
EUR 183.6

Genorise® Human Lp-PLA2 cDNA Clone, 10 ug
GR154007 10 µg
EUR 183.6

Genorise® Human PAPP-A cDNA Clone, 10 ug
GR154013 10 µg
EUR 183.6

Genorise® Human NT-proBNP cDNA Clone, 10 ug
GR154014 10 µg
EUR 183.6

Genorise® Human Pro-C3 cDNA Clone, 10 ug
GR154015 10 µg
EUR 183.6

Genorise® Canine NGF-B cDNA Clone, 10 ug
GR159001 10 µg
EUR 183.6

Genorise® Canine IL-7 cDNA Clone, 10 ug
GR159002 10 µg
EUR 183.6

CCR6 Blocking Peptide
DF10207-BP 1mg
EUR 234

CCR6 Conjugated Antibody
C37466 100ul
EUR 476.4

CCR6 cloning plasmid
CSB-CL004845HU-10ug 10ug
EUR 279.6
Description: A cloning plasmid for the CCR6 gene.

CCR6 Blocking Peptide
20-abx061923
  • EUR 309.60
  • EUR 460.80
  • 1 mg
  • 5 mg

CCR6 Rabbit pAb
A16206-100ul 100 ul
EUR 369.6

CCR6 Rabbit pAb
A16206-200ul 200 ul
EUR 550.8

CCR6 Rabbit pAb
A16206-20ul 20 ul
EUR 219.6

CCR6 Rabbit pAb
A16206-50ul 50 ul
EUR 267.6

Anti-CCR6 Antibody
A00957 100ug/vial
EUR 400.8

Anti-CCR6 Antibody
A00061-1 200ug
EUR 476.4
Description: Goat Polyclonal CCR6 Antibody. Validated in ELISA, IHC and tested in Human, Mouse.

CCR6 inhibitor 1
HY-112701 10mg
EUR 1093.2

Anti-CCR6 Antibody
STJ500414 100 µg
EUR 571.2

Anti-CCR6 antibody
STJ118659 100 µl
EUR 332.4

CCR6 Polyclonal Antibody
A70457-050 50 ul
EUR 302.5

CCR6 Polyclonal Antibody
A70457-100 100 ul
EUR 423.5

CCR6 Polyclonal Antibody
A50105-020 20 ul Ask for price

CCR6 Polyclonal Antibody
A50105-050 50 ul Ask for price

CCR6 Polyclonal Antibody
A50105-100 100 ul
EUR 423.5

CCR6 Polyclonal Antibody
A50105
  • EUR 684.66
  • Ask for price
  • Ask for price
  • EUR 423.50
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

CCR6 Polyclonal Antibody
A70457
  • EUR 302.50
  • EUR 423.50
  • 50 ul
  • 100 ul

CCR6 Antibody, HRP conjugated
1-CSB-PA004845EB01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against CCR6. Recognizes CCR6 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

CCR6 Antibody, FITC conjugated
1-CSB-PA004845EC01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against CCR6. Recognizes CCR6 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

CCR6 Antibody, Biotin conjugated
1-CSB-PA004845ED01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against CCR6. Recognizes CCR6 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

Mouse CCR6 shRNA Plasmid
20-abx969534
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Human CCR6 shRNA Plasmid
20-abx950871
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Human CCR6 ELISA Kit
ELA-E2014h 96 Tests
EUR 988.8

CCR6 ELISA KIT|Human
EF006138 96 Tests
EUR 826.8

Anti-CCR6 Antibody (Biotin)
STJ500416 100 µg
EUR 703.2

Anti-CCR6 Antibody (FITC)
STJ500417 100 µg
EUR 703.2

CCR6 Recombinant Protein (Human)
RP006232 100 ug Ask for price

CCR6 Recombinant Protein (Mouse)
RP122255 100 ug Ask for price

CCR6 Recombinant Protein (Mouse)
RP122258 100 ug Ask for price

CCR6 Recombinant Protein (Mouse)
RP122261 100 ug Ask for price

CCR6 Recombinant Protein (Mouse)
RP122264 100 ug Ask for price

CCR6 Recombinant Protein (Mouse)
RP122267 100 ug Ask for price

CCR6 Recombinant Protein (Mouse)
RP122270 100 ug Ask for price

CCR6 Recombinant Protein (Mouse)
RP122273 100 ug Ask for price

CCR6 Recombinant Protein (Rat)
RP193790 100 ug Ask for price

cDNA Synthesis SuperMix
20-abx09801420ulSystems
  • EUR 678.00
  • EUR 577.20
  • 100 rxns × 20 ul Systems
  • 50 rxns × 20 ul Systems

Novo? cDNA Kit
M1165-100
EUR 424.8

Novo? cDNA Kit
M1165-25
EUR 320.4

Evo? cDNA Supermix
M1168-100
EUR 457.2

Evo? cDNA Supermix
M1168-25
EUR 320.4

Novo? cDNA Supermix
M1169-100
EUR 529.2

Novo? cDNA Supermix
M1169-25
EUR 346.8

cDNA from Plant Normal Tissue: cDNA from Plant: Arabidopsis
C1634310 40 reactions
EUR 745.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Plant Normal Tissue: cDNA from Plant: Corn
C1634330 40 reactions
EUR 745.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Plant Normal Tissue: cDNA from Plant: Orange
C1634340 40 reactions
EUR 745.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Plant Normal Tissue: cDNA from Plant: Potato
C1634350 40 reactions
EUR 745.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Plant Normal Tissue: cDNA from Plant: Rice
C1634360 40 reactions
EUR 745.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Plant Normal Tissue: cDNA from Plant: Wheat
C1634390 40 reactions
EUR 745.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Polyclonal CCR6 Antibody (C-Terminus)
APR15281G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human CCR6 (C-Terminus). This antibody is tested and proven to work in the following applications:

Polyclonal CCR6 Antibody (Cytoplasmic Domain)
APR15282G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human CCR6 (Cytoplasmic Domain). This antibody is tested and proven to work in the following applications:

Polyclonal CCR6 Antibody (Extracellular Domain)
APR15283G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human CCR6 (Extracellular Domain). This antibody is tested and proven to work in the following applications:

Polyclonal CCR6 Antibody (aa18-46)
APR15308G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human CCR6 (aa18-46). This antibody is tested and proven to work in the following applications:

CCR6 ELISA Kit (Human) (OKAN05540)
OKAN05540 96 Wells
EUR 950.4
Description: Description of target: This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.058 ng/mL

CCR6 ELISA Kit (Mouse) (OKEH03436)
OKEH03436 96 Wells
EUR 794.4
Description: Description of target: Receptor for the C-C type chemokine CCL20. Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels (PubMed:20068036). Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins (PubMed:25122636). Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity. Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects (PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCR6-mediated signals are essential for immune responses to microbes in the intestinal mucosa and in the modulation of inflammatory responses initiated by tissue insult and trauma (PubMed:21376174). CCR6 is essential for the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation (PubMed:19050256). Required for the normal migration of Th17 cells in Peyers patches and other related tissue sites of the intestine and plays a role in regulating effector T-cell balance and distribution in inflamed intestine (PubMed:19129757). Plays an important role in the coordination of early thymocyte precursor migration events important for normal subsequent thymocyte precursor development, but is not required for the formation of normal thymic natural regulatory T-cells (nTregs). Required for optimal differentiation of DN2 and DN3 thymocyte precursors (PubMed:24638065). Essential for B-cell localization in the subepithelial dome of Peyers-patches and for efficient B-cell isotype switching to IgA in the Peyers-patches (PubMed:27174992). Essential for appropriate anatomical distribution of memory B-cells in the spleen and for the secondary recall response of memory B-cells (PubMed:25505290). Positively regulates sperm motility and chemotaxis via its binding to CCL20 (PubMed:23765988).;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.092 ng/mL

Ccr6 ORF Vector (Rat) (pORF)
ORF064598 1.0 ug DNA
EUR 607.2

CCR6 ORF Vector (Human) (pORF)
ORF002078 1.0 ug DNA
EUR 114

CCR6 ELISA Kit (Human) (OKCD07908)
OKCD07908 96 Wells
EUR 1170
Description: Description of target: This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: < 0.058ng/mL

CCR6 ELISA Kit (Mouse) (OKCD07909)
OKCD07909 96 Wells
EUR 1201.2
Description: Description of target: Receptor for the C-C type chemokine CCL20. Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels (PubMed:20068036). Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins (PubMed:25122636). Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity. Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects (PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCR6-mediated signals are essential for immune responses to microbes in the intestinal mucosa and in the modulation of inflammatory responses initiated by tissue insult and trauma (PubMed:21376174). CCR6 is essential for the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation (PubMed:19050256). Required for the normal migration of Th17 cells in Peyers patches and other related tissue sites of the intestine and plays a role in regulating effector T-cell balance and distribution in inflamed intestine (PubMed:19129757). Plays an important role in the coordination of early thymocyte precursor migration events important for normal subsequent thymocyte precursor development, but is not required for the formation of normal thymic natural regulatory T-cells (nTregs). Required for optimal differentiation of DN2 and DN3 thymocyte precursors (PubMed:24638065). Essential for B-cell localization in the subepithelial dome of Peyers-patches and for efficient B-cell isotype switching to IgA in the Peyers-patches (PubMed:27174992). Essential for appropriate anatomical distribution of memory B-cells in the spleen and for the secondary recall response of memory B-cells (PubMed:25505290). Positively regulates sperm motility and chemotaxis via its binding to CCL20 (PubMed:23765988).;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: < 0.053ng/mL

Ccr6 ORF Vector (Mouse) (pORF)
ORF040753 1.0 ug DNA
EUR 607.2

Ccr6 ORF Vector (Mouse) (pORF)
ORF040754 1.0 ug DNA
EUR 607.2

Ccr6 ORF Vector (Mouse) (pORF)
ORF040755 1.0 ug DNA
EUR 607.2

Ccr6 ORF Vector (Mouse) (pORF)
ORF040756 1.0 ug DNA
EUR 607.2

Ccr6 ORF Vector (Mouse) (pORF)
ORF040757 1.0 ug DNA
EUR 607.2

Ccr6 ORF Vector (Mouse) (pORF)
ORF040758 1.0 ug DNA
EUR 607.2

Ccr6 ORF Vector (Mouse) (pORF)
ORF040759 1.0 ug DNA
EUR 607.2

h CCR6 inducible lentiviral particles
LVP513 1x107 IFU/ml x 200ul
EUR 541.2
Description: Pre-made optional inducible lentiviral particles for expressing human target: h CCR6 inducible lentiviral particles (alternative name: BN-1, C-C CKR-6, CC-CKR-6, CCR-6, CD196, CKR-L3, CKRL3, CMKBR6, DCR2, DRY6, GPR29, GPRCY4, STRL22). The sub-cloned codon sequence is identical (100% match) to CDS region in NCBI ID: NM_004367.5. Particles also contains a RFP-Blasticidin dual selection marker.

pECMV-Ccr6-m-FLAG Plasmid
PVT14903 2 ug
EUR 390

pECMV-Ccr6-m-FLAG Plasmid
PVT15327 2 ug
EUR 390

CCR6 Polyclonal Antibody, HRP Conjugated
A50106-050 50 ul
EUR 302.5

CCR6 Polyclonal Antibody, HRP Conjugated
A50106-100 100 ul
EUR 423.5

CCR6 Polyclonal Antibody, FITC Conjugated
A50107-050 50 ul
EUR 302.5

CCR6 Polyclonal Antibody, FITC Conjugated
A50107-100 100 ul
EUR 423.5

CCR6 Polyclonal Antibody, Biotin Conjugated
A50108-050 50 ul
EUR 302.5

CCR6 Polyclonal Antibody, Biotin Conjugated
A50108-100 100 ul
EUR 423.5

CCR6 Polyclonal Antibody, HRP Conjugated
A50106
  • EUR 684.66
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 50 ul
  • 100 ul

CCR6 Polyclonal Antibody, FITC Conjugated
A50107
  • EUR 684.66
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 50 ul
  • 100 ul

CCR6 Polyclonal Antibody, Biotin Conjugated
A50108
  • EUR 684.66
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 50 ul
  • 100 ul

cDNA from Plant Normal Tissue: cDNA from Plant: Soy bean
C1634370 40 reactions
EUR 745.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

First-Strand cDNA Synthesis SuperMix (cDNA up to 12 kb)
20-abx09801620ulSystems
  • EUR 744.00
  • EUR 627.60
  • 100 rxns × 20 ul Systems
  • 50 rxns × 20 ul Systems

First-Strand cDNA Synthesis SuperMix (cDNA up to 15 kb)
20-abx09802120ulSystems
  • EUR 1045.20
  • EUR 794.40
  • 100 rxns × 20 ul Systems
  • 50 rxns × 20 ul Systems

cDNA from Arteriosclerosis: Aorta
C1236012Hd-4 40 reactions
EUR 973.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from hypertension: Artery
C1236013Hd-2 40 reactions
EUR 801.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Arteriosclerosis: Artery
C1236013Hd-4 40 reactions
EUR 973.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from hypertension: Vein
C1236020Hd-2 40 reactions
EUR 801.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Lupus: Colon
C1236090Lup 40 reactions
EUR 801.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from hypertension: Heart
C1236122Hd-2 40 reactions
EUR 801.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Lupus: Heart
C1236122Lup 40 reactions
EUR 801.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from hypertension: Kidney
C1236142Hd-2 40 reactions
EUR 801.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Lupus: Kidney
C1236142Lup 40 reactions
EUR 801.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Lupus: Liver
C1236149Lup 40 reactions
EUR 801.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Asthma: Lung
C1236152Ld-1 40 reactions
EUR 973.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Bronchitis: Lung
C1236152Ld-2 40 reactions
EUR 973.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Emphysema: Lung
C1236152Ld-3 40 reactions
EUR 973.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Pneumonia: Lung
C1236152Ld-4 40 reactions
EUR 973.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Lupus: Lung
C1236152Lup 40 reactions
EUR 801.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Lupus: Pancreas
C1236188Lup 40 reactions
EUR 801.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Lupus: Spleen
C1236246Lup 40 reactions
EUR 801.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Lupus: stomach
C1236248Lup 40 reactions
EUR 801.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Human eNOS cDNA probe
eNOS51-D-2 2 ug
EUR 534

Tetro cDNA Synthesis Kit
BIO-65042 30 Reactions Ask for price

Tetro cDNA Synthesis Kit
BIO-65043 100 Reactions Ask for price

SensiFAST cDNA Synthesis Kit
BIO-65053 50 Reactions Ask for price

SensiFAST cDNA Synthesis Kit
BIO-65053/S Sample Ask for price

SensiFAST cDNA Synthesis Kit
BIO-65054 250 Reactions Ask for price

cDNA Probe Diluent Solution
AR0063 5mL
EUR 127.2

Evo™ cDNA Kit
M1164-100 Ask for price

Evo™ cDNA Kit
M1164-25 Ask for price

Novo? Transcriptome cDNA Kit
M1167-100
EUR 1142.4

Novo? Transcriptome cDNA Kit
M1167-25
EUR 529.2

OneScriptPlus cDNA Synthesis Kit
G235 25 x 20 ul reactions
EUR 116.4

OneScriptPlus cDNA Synthesis Kit
G236 100 x 20 ul reactions
EUR 202.8

OneScriptPlus cDNA Synthesis SuperMix
G453 25 x 20 ul reactions
EUR 116.4

OneScriptPlus cDNA Synthesis SuperMix
G454 100 x 20 ul reactions
EUR 202.8

circRNA cDNA Synthesis Kit
G627 25 rxn (20 ul/rxn)
EUR 370.8

Plant Tissue cDNA: Arabidopsis
PC34-310 10 rxn
EUR 498

Human Chemokine C-C-Motif Receptor 6 (CCR6) ELISA Kit
SEC014Hu-10x96wellstestplate 10x96-wells test plate
EUR 5677.8
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Chemokine C-C-Motif Receptor 6 (CCR6) in tissue homogenates, cell lysates and other biological fluids.

Human Chemokine C-C-Motif Receptor 6 (CCR6) ELISA Kit
SEC014Hu-1x48wellstestplate 1x48-wells test plate
EUR 572.76
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Chemokine C-C-Motif Receptor 6 (CCR6) in tissue homogenates, cell lysates and other biological fluids.

Human Chemokine C-C-Motif Receptor 6 (CCR6) ELISA Kit
SEC014Hu-1x96wellstestplate 1x96-wells test plate
EUR 766.8
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Chemokine C-C-Motif Receptor 6 (CCR6) in tissue homogenates, cell lysates and other biological fluids.

Human Chemokine C-C-Motif Receptor 6 (CCR6) ELISA Kit
SEC014Hu-5x96wellstestplate 5x96-wells test plate
EUR 3090.6
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Chemokine C-C-Motif Receptor 6 (CCR6) in tissue homogenates, cell lysates and other biological fluids.

Human Chemokine C-C-Motif Receptor 6 (CCR6) ELISA Kit
4-SEC014Hu
  • EUR 5738.40
  • EUR 3031.20
  • EUR 768.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Chemokine C-C-Motif Receptor 6 (CCR6) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Mouse Chemokine C-C-Motif Receptor 6 (CCR6) ELISA Kit
SEC014Mu-10x96wellstestplate 10x96-wells test plate
EUR 5834.88
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Chemokine C-C-Motif Receptor 6 (CCR6) in Tissue homogenates, cell lysates and other biological fluids.

Mouse Chemokine C-C-Motif Receptor 6 (CCR6) ELISA Kit
SEC014Mu-1x48wellstestplate 1x48-wells test plate
EUR 585.7
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Chemokine C-C-Motif Receptor 6 (CCR6) in Tissue homogenates, cell lysates and other biological fluids.

Mouse Chemokine C-C-Motif Receptor 6 (CCR6) ELISA Kit
SEC014Mu-1x96wellstestplate 1x96-wells test plate
EUR 785.28
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Chemokine C-C-Motif Receptor 6 (CCR6) in Tissue homogenates, cell lysates and other biological fluids.

Mouse Chemokine C-C-Motif Receptor 6 (CCR6) ELISA Kit
SEC014Mu-5x96wellstestplate 5x96-wells test plate
EUR 3173.76
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Chemokine C-C-Motif Receptor 6 (CCR6) in Tissue homogenates, cell lysates and other biological fluids.

Mouse Chemokine C-C-Motif Receptor 6 (CCR6) ELISA Kit
4-SEC014Mu
  • EUR 5895.60
  • EUR 3114.00
  • EUR 786.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Chemokine C-C-Motif Receptor 6 (CCR6) in samples from Tissue homogenates, cell lysates and other biological fluids. with no significant corss-reactivity with analogues from other species.

CCR6 sgRNA CRISPR Lentivector set (Human)
K0395201 3 x 1.0 ug
EUR 406.8

Nori® Human CCR6 ELISA Kit
GR111529 96-well
EUR 553.2

Ccr6 sgRNA CRISPR Lentivector set (Rat)
K7215601 3 x 1.0 ug
EUR 406.8

Ccr6 sgRNA CRISPR Lentivector set (Mouse)
K4422401 3 x 1.0 ug
EUR 406.8

Nori® Canine CCR6 ELISA Kit
GR115500 96-well
EUR 553.2

Nori® Rat CCR6 ELISA Kit
GR118372 96-well
EUR 553.2
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