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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

  May 25, 2021
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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide substitutions and epigenetic modifications that drive malignant transformation. The Cancer Genome Atlas (TCGA) pilot project aims to assess the value of large-scale multi-dimensional analysis of these molecular characteristics in human cancer and to provide the data rapidly to the research community.
Here we report the interim integrative analysis of DNA copy number, gene expression and DNA methylation aberrations in 206 glioblastomas–the most common type of adult brain cancer–and nucleotide sequence aberrations in 91 of the 206 glioblastomas. This analysis provides new insights into the roles of ERBB2, NF1 and TP53, uncovers frequent mutations of the phosphatidylinositol-3-OH kinase regulatory subunit gene PIK3R1, and provides a network view of the pathways altered in the development of glioblastoma.

Rabbit Heat Shock Protein 40 (HSP-40) ELISA Kit
AE39296RB-96Tests 96 Tests
EUR 680
Description: Rabbit (Oryctolagus cuniculus)

Rabbit Heat Shock Protein 40,HSP-40 ELISA Kit
GA-E0088RB-48T 48T
EUR 391.2

Rabbit Heat Shock Protein 40,HSP-40 ELISA Kit
GA-E0088RB-48Tests 48 Tests Ask for price

Rabbit Heat Shock Protein 40,HSP-40 ELISA Kit
GA-E0088RB-96T 96T
EUR 628.8

Rabbit Heat Shock Protein 40,HSP-40 ELISA Kit
GA-E0088RB-96Tests 96 Tests
EUR 450

Rabbit heat shock protein 40(Hsp-40) ELISA Kit
EIA05821Rb each
EUR 520

Rabbit heat shock protein 40 (Hsp-40) ELISA Kit
MBS2600311-10x96StripWells 10x96-Strip-Wells
EUR 3545

Rabbit heat shock protein 40 (Hsp-40) ELISA Kit
MBS2600311-48StripWells 48-Strip-Wells
EUR 310

Rabbit heat shock protein 40 (Hsp-40) ELISA Kit
MBS2600311-5x96StripWells 5x96-Strip-Wells
EUR 1940

Rabbit heat shock protein 40 (Hsp-40) ELISA Kit
MBS2600311-96StripWells 96-Strip-Wells
EUR 475

Rabbit Heat Shock Protein 40 (HSP-40) ELISA Kit
MBS285658-10x96StripWells 10x96-Strip-Wells
EUR 6840

Rabbit Heat Shock Protein 40 (HSP-40) ELISA Kit
MBS285658-48StripWells 48-Strip-Wells
EUR 480

Rabbit Heat Shock Protein 40 (HSP-40) ELISA Kit
MBS285658-5x96StripWells 5x96-Strip-Wells
EUR 3610

Rabbit Heat Shock Protein 40 (HSP-40) ELISA Kit
MBS285658-96StripWells 96-Strip-Wells
EUR 805

Rabbit Heat Shock Protein 40,HSP-40 ELISA Kit
QY-E30211 96T
EUR 448.8

Rabbit Heat Shock Protein 40,HSP-40 ELISA Kit
SL0087Rb -
EUR 498

Rabbit HSP-40 (Heat Shock Protein 40) ELISA Kit
MBS2510100-10x96Tests 10x96Tests
EUR 4445

Rabbit HSP-40 (Heat Shock Protein 40) ELISA Kit
MBS2510100-24Tests 24Tests
EUR 280

Rabbit HSP-40 (Heat Shock Protein 40) ELISA Kit
MBS2510100-48Tests 48Tests
EUR 495

Rabbit HSP-40 (Heat Shock Protein 40) ELISA Kit
MBS2510100-5x96Tests 5x96Tests
EUR 2480

Rabbit HSP-40 (Heat Shock Protein 40) ELISA Kit
MBS2510100-96Tests 96Tests
EUR 585

Rat heat shock protein 40,hSP-40 ELISA Kit
CN-01864R1 96T
EUR 538.8

Rat heat shock protein 40(hSP-40)ELISA Kit
GA-E0527RT-48T 48T
EUR 380.4

Rat heat shock protein 40(hSP-40)ELISA Kit
GA-E0527RT-48Tests 48 Tests Ask for price

Rat heat shock protein 40(hSP-40)ELISA Kit
GA-E0527RT-96T 96T
EUR 595.2

Rat heat shock protein 40(hSP-40)ELISA Kit
GA-E0527RT-96Tests 96 Tests
EUR 420

Rat heat shock protein 40(HSP-40) Elisa Kit
EK720496 96 Wells
EUR 0.57

Rat heat shock protein 40(Hsp-40) ELISA Kit
EIA05821r each
EUR 480

Pig Heat Shock Protein 40 (HSP-40) ELISA Kit
MBS283119-10x96StripWells 10x96-Strip-Wells
EUR 6840

Pig Heat Shock Protein 40 (HSP-40) ELISA Kit
MBS283119-48StripWells 48-Strip-Wells
EUR 480

Pig Heat Shock Protein 40 (HSP-40) ELISA Kit
MBS283119-5x96StripWells 5x96-Strip-Wells
EUR 3610

Pig Heat Shock Protein 40 (HSP-40) ELISA Kit
MBS283119-96StripWells 96-Strip-Wells
EUR 805

Rat Heat Shock Protein 40, hSP-40 ELISA Kit
MBS164395-10x96StripWells 10x96-Strip-Wells
EUR 3955

Rat Heat Shock Protein 40, hSP-40 ELISA Kit
MBS164395-48StripWells 48-Strip-Wells
EUR 305

Rat Heat Shock Protein 40, hSP-40 ELISA Kit
MBS164395-5x96StripWells 5x96-Strip-Wells
EUR 2005

Rat Heat Shock Protein 40, hSP-40 ELISA Kit
MBS164395-96StripWells 96-Strip-Wells
EUR 475

Rat heat shock protein 40 (Hsp-40) ELISA Kit
MBS260312-10x96StripWells 10x96-Strip-Wells
EUR 3290

Rat heat shock protein 40 (Hsp-40) ELISA Kit
MBS260312-48StripWells 48-Strip-Wells
EUR 295

Rat heat shock protein 40 (Hsp-40) ELISA Kit
MBS260312-5x96StripWells 5x96-Strip-Wells
EUR 1800

Rat heat shock protein 40 (Hsp-40) ELISA Kit
MBS260312-96StripWells 96-Strip-Wells
EUR 450

Rat heat shock protein 40, hSP-40 ELISA Kit
MBS9303774-10x96StripWells 10x96-Strip-Wells
EUR 6725

Rat heat shock protein 40, hSP-40 ELISA Kit
MBS9303774-48StripWells 48-Strip-Wells
EUR 550

Rat heat shock protein 40, hSP-40 ELISA Kit
MBS9303774-5x96StripWells 5x96-Strip-Wells
EUR 3420

Rat heat shock protein 40, hSP-40 ELISA Kit
MBS9303774-96StripWells 96-Strip-Wells
EUR 765

Rat Heat shock protein 40(Hsp-40) ELISA Kit
NSL0481r 96 Tests
EUR 498
Description: Sandwich ELISA

Rat heat shock protein 40,hSP-40 ELISA Kit
SL0334Ra -
EUR 498

Rat heat shock protein 40,hSP-40 ELISA Kit
YLA1006RA-48T 48T Ask for price

Rat heat shock protein 40,hSP-40 ELISA Kit
YLA1006RA-96T 96T Ask for price

Goat heat shock protein 40(Hsp-40) ELISA Kit
EIA05821Go each
EUR 520

Fish Heat Shock Protein 40 (HSP-40) ELISA Kit
MBS280962-10x96StripWells 10x96-Strip-Wells
EUR 6840

Fish Heat Shock Protein 40 (HSP-40) ELISA Kit
MBS280962-48StripWells 48-Strip-Wells
EUR 480

Fish Heat Shock Protein 40 (HSP-40) ELISA Kit
MBS280962-5x96StripWells 5x96-Strip-Wells
EUR 3610

Fish Heat Shock Protein 40 (HSP-40) ELISA Kit
MBS280962-96StripWells 96-Strip-Wells
EUR 805

Goat heat shock protein 40 (Hsp-40) ELISA Kit
MBS261805-10x96StripWells 10x96-Strip-Wells
EUR 3545

Goat heat shock protein 40 (Hsp-40) ELISA Kit
MBS261805-48StripWells 48-Strip-Wells
EUR 310

Goat heat shock protein 40 (Hsp-40) ELISA Kit
MBS261805-5x96StripWells 5x96-Strip-Wells
EUR 1940

Goat heat shock protein 40 (Hsp-40) ELISA Kit
MBS261805-96StripWells 96-Strip-Wells
EUR 475

Goat Heat shock protein 40(Hsp-40) ELISA Kit
NSL0606Gt 96T
EUR 528
Description: Sandwich ELISA

Human Heat Shock Protein 40,HSP-40 ELISA Kit
201-12-1770 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Mouse Heat Shock Protein 40,Hsp-40 ELISA Kit
CN-02742M1 96T
EUR 548.4

Mouse Heat Shock Protein 40,Hsp-40 ELISA Kit
CN-02742M2 48T
EUR 367.2

Human Heat Shock Protein 40,HSP-40 ELISA Kit
CN-03555H1 96T
EUR 567.6

Human Heat Shock Protein 40,HSP-40 ELISA Kit
CN-03555H2 48T
EUR 387.6

Mouse Heat Shock Protein 40(Hsp-40)ELISA Kit
GA-E0316MS-48T 48T
EUR 403.2

Mouse Heat Shock Protein 40(Hsp-40)ELISA Kit
GA-E0316MS-48Tests 48 Tests Ask for price

Mouse Heat Shock Protein 40(Hsp-40)ELISA Kit
GA-E0316MS-96T 96T
EUR 640.8

Mouse Heat Shock Protein 40(Hsp-40)ELISA Kit
GA-E0316MS-96Tests 96 Tests
EUR 460

Human Heat Shock Protein 40(HSP-40)ELISA Kit
GA-E1786HM-48T 48T
EUR 346.8

Human Heat Shock Protein 40(HSP-40)ELISA Kit
GA-E1786HM-48Tests 48 Tests Ask for price

Human Heat Shock Protein 40(HSP-40)ELISA Kit
GA-E1786HM-96T 96T
EUR 559.2

Human Heat Shock Protein 40(HSP-40)ELISA Kit
GA-E1786HM-96Tests 96 Tests
EUR 388

Mouse Heat Shock Protein 40,Hsp-40 Elisa Kit
EK730170 96 Wells
EUR 0.66

Human Heat Shock Protein 40(HSP-40) Elisa Kit
EK711018 96 Wells
EUR 0.13

Human heat shock protein 40(Hsp-40) ELISA Kit
EIA05821h each
EUR 430

Mouse heat shock protein 40(Hsp-40) ELISA Kit
EIA05821m each
EUR 480

Mouse heat shock protein 40 (Hsp-40) ELISA Kit
MBS265826-10x96StripWells 10x96-Strip-Wells
EUR 3290

Mouse heat shock protein 40 (Hsp-40) ELISA Kit
MBS265826-48StripWells 48-Strip-Wells
EUR 295

Mouse heat shock protein 40 (Hsp-40) ELISA Kit
MBS265826-5x96StripWells 5x96-Strip-Wells
EUR 1800

Mouse heat shock protein 40 (Hsp-40) ELISA Kit
MBS265826-96StripWells 96-Strip-Wells
EUR 450

Mouse Heat Shock Protein 40, Hsp-40 ELISA Kit
MBS165276-10x96StripWells 10x96-Strip-Wells
EUR 3955

Mouse Heat Shock Protein 40, Hsp-40 ELISA Kit
MBS165276-48StripWells 48-Strip-Wells
EUR 305

Mouse Heat Shock Protein 40, Hsp-40 ELISA Kit
MBS165276-5x96StripWells 5x96-Strip-Wells
EUR 2005

Mouse Heat Shock Protein 40, Hsp-40 ELISA Kit
MBS165276-96StripWells 96-Strip-Wells
EUR 475

Human Heat Shock Protein 40, HSP-40 ELISA Kit
MBS163209-10x96StripWells 10x96-Strip-Wells
EUR 3460

Human Heat Shock Protein 40, HSP-40 ELISA Kit
MBS163209-48StripWells 48-Strip-Wells
EUR 285

Human Heat Shock Protein 40, HSP-40 ELISA Kit
MBS163209-5x96StripWells 5x96-Strip-Wells
EUR 1750

Human Heat Shock Protein 40, HSP-40 ELISA Kit
MBS163209-96StripWells 96-Strip-Wells
EUR 425

Human heat shock protein 40 (Hsp-40) ELISA Kit
MBS262312-10x96StripWells 10x96-Strip-Wells
EUR 3040

Human heat shock protein 40 (Hsp-40) ELISA Kit
MBS262312-48StripWells 48-Strip-Wells
EUR 285

Human heat shock protein 40 (Hsp-40) ELISA Kit
MBS262312-5x96StripWells 5x96-Strip-Wells
EUR 1670

Human heat shock protein 40 (Hsp-40) ELISA Kit
MBS262312-96StripWells 96-Strip-Wells
EUR 405

Mouse Heat Shock Protein 40, Hsp-40 ELISA Kit
MBS9304537-10x96StripWells 10x96-Strip-Wells
EUR 6725

Mouse Heat Shock Protein 40, Hsp-40 ELISA Kit
MBS9304537-48StripWells 48-Strip-Wells
EUR 550

Mouse Heat Shock Protein 40, Hsp-40 ELISA Kit
MBS9304537-5x96StripWells 5x96-Strip-Wells
EUR 3420

Mouse Heat Shock Protein 40, Hsp-40 ELISA Kit
MBS9304537-96StripWells 96-Strip-Wells
EUR 765

Human Heat Shock Protein 40, HSP-40 ELISA Kit
MBS9302750-10x96StripWells 10x96-Strip-Wells
EUR 6725

Human Heat Shock Protein 40, HSP-40 ELISA Kit
MBS9302750-48StripWells 48-Strip-Wells
EUR 550

Human Heat Shock Protein 40, HSP-40 ELISA Kit
MBS9302750-5x96StripWells 5x96-Strip-Wells
EUR 3420

Human Heat Shock Protein 40, HSP-40 ELISA Kit
MBS9302750-96StripWells 96-Strip-Wells
EUR 765

Human heat shock protein 40(Hsp-40)ELISA Kit
NSL1987Hu 96 wells
EUR 468
Description: Sandwich ELISA

Mouse Heat Shock Protein 40,Hsp-40 ELISA Kit
SL0254Mo -
EUR 528

Human Heat Shock Protein 40,HSP-40 ELISA Kit
SL0828Hu 96 Tests
EUR 468

Mouse Heat Shock Protein 40,Hsp-40 ELISA Kit
YLA0764MO-48T 48T Ask for price

Mouse Heat Shock Protein 40,Hsp-40 ELISA Kit
YLA0764MO-96T 96T Ask for price

Human Heat Shock Protein 40,HSP-40 ELISA Kit
YLA2764HU-48T 48T Ask for price

Human Heat Shock Protein 40,HSP-40 ELISA Kit
YLA2764HU-96T 96T Ask for price

Bovine heat shock protein 40(Hsp-40) ELISA Kit
EIA05821Bo each
EUR 520

Canine heat shock protein 40(Hsp-40) ELISA Kit
EIA05821Ca each
EUR 520

Bovine heat shock protein 40(Hsp-40) ELISA Kit
MBS2609290-10x96StripWells 10x96-Strip-Wells
EUR 3545

Bovine heat shock protein 40(Hsp-40) ELISA Kit
MBS2609290-48StripWells 48-Strip-Wells
EUR 310

Bovine heat shock protein 40(Hsp-40) ELISA Kit
MBS2609290-5x96StripWells 5x96-Strip-Wells
EUR 1940

Bovine heat shock protein 40(Hsp-40) ELISA Kit
MBS2609290-96StripWells 96-Strip-Wells
EUR 475

Canine heat shock protein 40 (Hsp-40) ELISA Kit
MBS2605638-10x96StripWells 10x96-Strip-Wells
EUR 3545

Canine heat shock protein 40 (Hsp-40) ELISA Kit
MBS2605638-48StripWells 48-Strip-Wells
EUR 310

Canine heat shock protein 40 (Hsp-40) ELISA Kit
MBS2605638-5x96StripWells 5x96-Strip-Wells
EUR 1940

Canine heat shock protein 40 (Hsp-40) ELISA Kit
MBS2605638-96StripWells 96-Strip-Wells
EUR 475

Bovine Heat shock protein 40(Hsp-40) ELISA Kit
NSL0396Bo 96 T
EUR 528
Description: Sandwich ELISA

Canine Heat shock protein 40(Hsp-40) ELISA Kit
NSL0472Ca 567 wells
EUR 528
Description: Sandwich ELISA

Chicken Heat Shock Protein 40,HSP-40 ELISA Kit
CN-00814C1 96T
EUR 546

Chicken Heat Shock Protein 40,HSP-40 ELISA Kit
CN-00814C2 48T
EUR 364.8

PoFAine Heat Shock Protein 40,HSP-40 ELISA Kit
CN-01299P1 96T
EUR 548.4

PoFAine Heat Shock Protein 40,HSP-40 ELISA Kit
CN-01299P2 48T
EUR 367.2

Porcine Heat Shock Protein 40,HSP-40 Elisa Kit
EK751034 96 Wells
EUR 0.87

Chicken heat shock protein 40(Hsp-40) ELISA Kit
EIA05821Ch each
EUR 520

Porcine heat shock protein 40(Hsp-40) ELISA Kit
EIA05821p each
EUR 520

Porcine heat shock protein 40 (Hsp-40) ELISA Kit
MBS264779-10x96StripWells 10x96-Strip-Wells
EUR 3545

Porcine heat shock protein 40 (Hsp-40) ELISA Kit
MBS264779-48StripWells 48-Strip-Wells
EUR 310

Porcine heat shock protein 40 (Hsp-40) ELISA Kit
MBS264779-5x96StripWells 5x96-Strip-Wells
EUR 1940

Porcine heat shock protein 40 (Hsp-40) ELISA Kit
MBS264779-96StripWells 96-Strip-Wells
EUR 475

Chicken heat shock protein 40 (Hsp-40) ELISA Kit
MBS264881-10x96StripWells 10x96-Strip-Wells
EUR 3545

Chicken heat shock protein 40 (Hsp-40) ELISA Kit
MBS264881-48StripWells 48-Strip-Wells
EUR 310

Chicken heat shock protein 40 (Hsp-40) ELISA Kit
MBS264881-5x96StripWells 5x96-Strip-Wells
EUR 1940

Chicken heat shock protein 40 (Hsp-40) ELISA Kit
MBS264881-96StripWells 96-Strip-Wells
EUR 475

Chicken Heat Shock Protein 40, HSP-40 ELISA Kit
MBS1601915-10x96StripWells 10x96-Strip-Wells
EUR 4470

Chicken Heat Shock Protein 40, HSP-40 ELISA Kit
MBS1601915-48StripWells 48-Strip-Wells
EUR 415

Chicken Heat Shock Protein 40, HSP-40 ELISA Kit
MBS1601915-5x96StripWells 5x96-Strip-Wells
EUR 2270

Chicken Heat Shock Protein 40, HSP-40 ELISA Kit
MBS1601915-96StripWells 96-Strip-Wells
EUR 540

Porcine Heat Shock Protein 40, HSP-40 ELISA Kit
MBS163395-10x96StripWells 10x96-Strip-Wells
EUR 4170

Porcine Heat Shock Protein 40, HSP-40 ELISA Kit
MBS163395-48StripWells 48-Strip-Wells
EUR 365

Porcine Heat Shock Protein 40, HSP-40 ELISA Kit
MBS163395-5x96StripWells 5x96-Strip-Wells
EUR 2115

Porcine Heat Shock Protein 40, HSP-40 ELISA Kit
MBS163395-96StripWells 96-Strip-Wells
EUR 505

Porcine Heat shock protein 40(Hsp-40) ELISA Kit
NSL0508Po 96T
EUR 528
Description: Sandwich ELISA

Chicken Heat shock protein 40(Hsp-40) ELISA Kit
NSL0660Ch 755 T
EUR 528
Description: Sandwich ELISA

Porcine Heat Shock Protein 40,HSP-40 ELISA Kit
SL0051Po -
EUR 528

Porcine Heat Shock Protein 40,HSP-40 ELISA Kit
YLA0293PO-48T 48T Ask for price

nordiag

Furthermore, integration of mutation, DNA methylation and clinical treatment data reveals a link between MGMT promoter methylation and a hypermutator phenotype consequent to mismatch repair deficiency in treated glioblastomas, an observation with potential clinical implications. Together, these findings establish the feasibility and power of TCGA, demonstrating that it can rapidly expand knowledge of the molecular basis of cancer.

The sequence of the human genome

A 2.91-billion base pair (bp) consensus sequence of the euchromatic portion of the human genome was generated by the whole-genome shotgun sequencing method. The 14.8-billion bp DNA sequence was generated over 9 months from 27,271,853 high-quality sequence reads (5.11-fold coverage of the genome) from both ends of plasmid clones made from the DNA of five individuals. Two assembly strategies-a whole-genome assembly and a regional chromosome assembly-were used, each combining sequence data from Celera and the publicly funded genome effort.
The public data were shredded into 550-bp segments to create a 2.9-fold coverage of those genome regions that had been sequenced, without including biases inherent in the cloning and assembly procedure used by the publicly funded group. This brought the effective coverage in the assemblies to eightfold, reducing the number and size of gaps in the final assembly over what would be obtained with 5.11-fold coverage. The two assembly strategies yielded very similar results that largely agree with independent mapping data. The assemblies effectively cover the euchromatic regions of the human chromosomes.
More than 90% of the genome is in scaffold assemblies of 100,000 bp or more, and 25% of the genome is in scaffolds of 10 million bp or larger. Analysis of the genome sequence revealed 26,588 protein-encoding transcripts for which there was strong corroborating evidence and an additional approximately 12,000 computationally derived genes with mouse matches or other weak supporting evidence.
Although gene-dense clusters are obvious, almost half the genes are dispersed in low G+C sequence separated by large tracts of apparently noncoding sequence. Only 1.1% of the genome is spanned by exons, whereas 24% is in introns, with 75% of the genome being intergenic DNA. Duplications of segmental blocks, ranging in size up to chromosomal lengths, are abundant throughout the genome and reveal a complex evolutionary history. Comparative genomic analysis indicates vertebrate expansions of genes associated with neuronal function, with tissue-specific developmental regulation, and with the hemostasis and immune systems.
DNA sequence comparisons between the consensus sequence and publicly funded genome data provided locations of 2.1 million single-nucleotide polymorphisms (SNPs). A random pair of human haploid genomes differed at a rate of 1 bp per 1250 on average, but there was marked heterogeneity in the level of polymorphism across the genome. Less than 1% of all SNPs resulted in variation in proteins, but the task of determining which SNPs have functional consequences remains an open challenge.

Arlequin (version 3.0): an integrated software package for population genetics data analysis

Arlequin ver 3.0 is a software package integrating several basic and advanced methods for population genetics data analysis, like the computation of standard genetic diversity indices, the estimation of allele and haplotype frequencies, tests of departure from linkage equilibrium, departure from selective neutrality and demographic equilibrium, estimation or parameters from past population expansions, and thorough analyses of population subdivision under the AMOVA framework.
Arlequin 3 introduces a completely new graphical interface written in C++, a more robust semantic analysis of input files, and two new methods: a Bayesian estimation of gametic phase from multi-locus genotypes, and an estimation of the parameters of an instantaneous spatial expansion from DNAsequence polymorphism. Arlequin can handle several data types like DNA sequences, microsatellite data, or standard multi-locus genotypes. A Windows version of the software is freely available on http://cmpg.unibe.ch/software/arlequin3.

Gene expression profiling predicts clinical outcome of breast cancer

Breast cancer patients with the same stage of disease can have markedly different treatment responses and overall outcome. The strongest predictors for metastases (for example, lymph node status and histological grade) fail to classify accurately breast tumours according to their clinical behaviour. Chemotherapy or hormonal therapy reduces the risk of distant metastases by approximately one-third; however, 70-80% of patients receiving this treatment would have survived without it.
None of the signatures of breast cancer gene expression reported to date allow for patient-tailored therapy strategies. Here we used DNA microarray analysis on primary breast tumours of 117 young patients, and applied supervised classification to identify a gene expression signature strongly predictive of a short interval to distant metastases (‘poor prognosis’ signature) in patients without tumour cells in local lymph nodes at diagnosis (lymph node negative).
In addition, we established a signature that identifies tumours of BRCA1 carriers. The poor prognosis signature consists of genes regulating cell cycle, invasion, metastasis and angiogenesis. This gene expression profile will outperform all currently used clinical parameters in predicting disease outcome. Our findings provide a strategy to select patients who would benefit from adjuvant therapy.

Polyclonal Dnalc4 antibody - middle region
APR15793G 0.05mg
EUR 633.6
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Dnalc4 - middle region. This antibody is tested and proven to work in the following applications:

ARP52101_P050-25UL - Dnalc4 Antibody - middle region
ARP52101_P050-25UL 25ul
EUR 99

ARP52101_P050 - Dnalc4 antibody - middle region (ARP52101_P050)
ARP52101_P050 100ul
EUR 389

Dnalc4 (GFP-tagged) - Mouse dynein, axonemal, light chain 4 (Dnalc4)
MG200362 10 µg Ask for price

Dnalc4 (Myc-DDK-tagged) - Mouse dynein, axonemal, light chain 4 (Dnalc4)
MR200362 10 µg Ask for price

Dnalc4 Peptide - middle region
MBS3235561-01mg 0.1mg
EUR 180

Dnalc4 Peptide - middle region
MBS3235561-5x01mg 5x0.1mg
EUR 730

Dnalc4 Recombinant Protein (Mouse)
RP129641 100 ug Ask for price

Dnalc4 ORF Vector (Mouse) (pORF)
ORF043215 1.0 ug DNA
EUR 607.2

Lenti ORF clone of Dnalc4 (mGFP-tagged) - Mouse dynein, axonemal, light chain 4 (Dnalc4)
MR200362L4 10 µg Ask for price

Lenti ORF clone of Dnalc4 (Myc-DDK-tagged) - Mouse dynein, axonemal, light chain 4 (Dnalc4)
MR200362L3 10 µg Ask for price

Lenti ORF particles, Dnalc4 (GFP-tagged) - Mouse dynein, axonemal, light chain 4 (Dnalc4), 200ul, >10^7 TU/mL
MR200362L4V 200 µl Ask for price

Dnalc4 sgRNA CRISPR Lentivector set (Mouse)
K4997501 3 x 1.0 ug
EUR 406.8

Dnalc4 3'UTR GFP Stable Cell Line
TU155288 1.0 ml Ask for price

Lenti ORF particles, Dnalc4 (Myc-DDK-tagged) - Mouse dynein, axonemal, light chain 4 (Dnalc4), 200ul, >10^7 TU/mL
MR200362L3V 200 µl Ask for price

Dnalc4 Protein Vector (Mouse) (pPM-C-HA)
PV172860 500 ng
EUR 723.6

Dnalc4 Protein Vector (Mouse) (pPB-C-His)
PV172858 500 ng
EUR 723.6

Dnalc4 Protein Vector (Mouse) (pPB-N-His)
PV172859 500 ng
EUR 723.6

Dnalc4 Protein Vector (Mouse) (pPM-C-His)
PV172861 500 ng
EUR 723.6

Dnalc4 3'UTR Luciferase Stable Cell Line
TU105288 1.0 ml Ask for price

Dnalc4 sgRNA CRISPR Lentivector (Mouse) (Target 1)
K4997502 1.0 ug DNA
EUR 184.8

Dnalc4 sgRNA CRISPR Lentivector (Mouse) (Target 2)
K4997503 1.0 ug DNA
EUR 184.8

Dnalc4 sgRNA CRISPR Lentivector (Mouse) (Target 3)
K4997504 1.0 ug DNA
EUR 184.8

Recombinant Mouse DNALC4 Protein, His (Fc)-Avi-tagged
DNALC4-2460M 50ug
EUR 2398.4
Description: For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.

Dnal4 (untagged) - Mouse dynein, axonemal, light chain 4 (Dnalc4), (10ug)
MC200472 10 µg Ask for price

Dnalc4 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)
K4997505 3 x 1.0 ug
EUR 451.2

Dnalc4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 1)
K4997506 1.0 ug DNA
EUR 200.4

Dnalc4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2)
K4997507 1.0 ug DNA
EUR 200.4

Dnalc4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 3)
K4997508 1.0 ug DNA
EUR 200.4

Dnalc1 Antibody - C-terminal region
MBS3215526-01mL 0.1mL
EUR 455

Dnalc1 Antibody - C-terminal region
MBS3215526-5x01mL 5x0.1mL
EUR 1995

ARP62201_P050-25UL - Dnalc1 Antibody - C-terminal region
ARP62201_P050-25UL 25ul
EUR 99

ARP62201_P050 - Dnalc1 Antibody - C-terminal region (ARP62201_P050)
ARP62201_P050 100ul
EUR 389

Dnalc4 - Mouse shRNA lentiviral particles (4 unique 29mer target-specific shRNA, 1 scramble control), 0.5 ml each, >10^7 TU/ml.
TL502994V 500 ul each Ask for price

Lenti ORF particles, Dnalc1 (GFP-tagged) - Mouse dynein, axonemal, light chain 1 (Dnalc1), 200ul, >10^7 TU/mL
MR216479L4V 200 µl Ask for price

Dnalc1 (GFP-tagged) - Mouse dynein axonemal light chain 1 (Dnalc1), (10ug)
MG216479 10 µg Ask for price

Dnalc1 (Myc-DDK-tagged) - Mouse dynein, axonemal, light chain 1 (Dnalc1)
MR216479 10 µg Ask for price

Lenti ORF particles, Dnalc1 (Myc-DDK-tagged) - Mouse dynein, axonemal, light chain 1 (Dnalc1), 200ul, >10^7 TU/mL
MR216479L3V 200 µl Ask for price

Lenti ORF clone of Dnalc1 (mGFP-tagged) - Mouse dynein, axonemal, light chain 1 (Dnalc1)
MR216479L4 10 µg Ask for price

Lenti ORF clone of Dnalc1 (Myc-DDK-tagged) - Mouse dynein, axonemal, light chain 1 (Dnalc1)
MR216479L3 10 µg Ask for price

Dnalc1 ORF Vector (Mouse) (pORF)
ORF043214 1.0 ug DNA
EUR 607.2

Dnalc1 3'UTR GFP Stable Cell Line
TU155287 1.0 ml Ask for price

Dnalc1 Peptide - C-terminal region
MBS3240429-01mg 0.1mg
EUR 180

Dnalc1 Peptide - C-terminal region
MBS3240429-5x01mg 5x0.1mg
EUR 730

Dnalc1 Protein Vector (Mouse) (pPM-C-HA)
PV172856 500 ng
EUR 723.6

Dnalc1 Protein Vector (Mouse) (pPB-C-His)
PV172854 500 ng
EUR 723.6

Dnalc1 Protein Vector (Mouse) (pPB-N-His)
PV172855 500 ng
EUR 723.6

Dnalc1 Protein Vector (Mouse) (pPM-C-His)
PV172857 500 ng
EUR 723.6

Dnalc1 3'UTR Luciferase Stable Cell Line
TU105287 1.0 ml Ask for price

Dnalc1 Recombinant Protein (Mouse)
RP129638 100 ug Ask for price

Dnalc1 sgRNA CRISPR Lentivector set (Mouse)
K4077601 3 x 1.0 ug
EUR 406.8

Dnal1 (untagged) - Mouse dynein, axonemal, light chain 1 (Dnalc1), (10ug)
MC212110 10 µg Ask for price

Dnalc1 sgRNA CRISPR Lentivector (Mouse) (Target 1)
K4077602 1.0 ug DNA
EUR 184.8

Dnalc1 sgRNA CRISPR Lentivector (Mouse) (Target 2)
K4077603 1.0 ug DNA
EUR 184.8

Dnalc1 sgRNA CRISPR Lentivector (Mouse) (Target 3)
K4077604 1.0 ug DNA
EUR 184.8

Recombinant Mouse DNALC1 Protein, His (Fc)-Avi-tagged
DNALC1-2459M 50ug
EUR 2398.4
Description: For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.

Dnalc1 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)
K4077605 3 x 1.0 ug
EUR 451.2

Dnalc1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 1)
K4077606 1.0 ug DNA
EUR 200.4

Dnalc1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2)
K4077607 1.0 ug DNA
EUR 200.4

Dnalc1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 3)
K4077608 1.0 ug DNA
EUR 200.4

Dnalc1 - Mouse shRNA lentiviral particles (4 unique 29mer target-specific shRNA, 1 scramble control), 0.5 ml each, >10^7 TU/ml.
TL505712V 500 ul each Ask for price

Somatostatin Analog D-2-Nal-Cys-Tyr-D-Trp-Lys-Val-Cys-Thr-NH2.
MBS658360-1mg 1mg
EUR 610

Somatostatin Analog D-2-Nal-Cys-Tyr-D-Trp-Lys-Val-Cys-Thr-NH2.
MBS658360-5x1mg 5x1mg
EUR 2600

Somatostatin Analog D-2-Nal-Cys-Tyr-D-Trp-Lys-Val-Cys-2-NaI-NH2
MBS659446-1mg 1mg
EUR 610

Somatostatin Analog D-2-Nal-Cys-Tyr-D-Trp-Lys-Val-Cys-2-NaI-NH2
MBS659446-5x1mg 5x1mg
EUR 2600

Somatostatin Analog D-2-Nal-cyclo(-gamma-Glu-Tyr-D-Trp-Lys-Val-L-alpha, gamma-diaminobutyryl)-Thr-NH2
MBS633712-1mg 1mg
EUR 610

Somatostatin Analog D-2-Nal-cyclo(-gamma-Glu-Tyr-D-Trp-Lys-Val-L-alpha, gamma-diaminobutyryl)-Thr-NH2
MBS633712-5x1mg 5x1mg
EUR 2600

DNAL4 Antibody
ABD9470 100 ug
EUR 525.6

DNAL1 Antibody
8C15512 50ug
EUR 368
Description: DNAL1 Antibody

DNAL4 Antibody
8C15515 50ug
EUR 368
Description: DNAL4 Antibody

DNAL4 Antibody
45946-100ul 100ul
EUR 302.4

DNAL4 Antibody
45946-50ul 50ul
EUR 224.4

DNAL1 Antibody
34660 100ul
EUR 319

DNAL1 Antibody
34660-100ul 100ul
EUR 302.4

DNAL1 Antibody
34660-50ul 50ul
EUR 224.4

DNAL1 antibody
70R-10420 50 ug
EUR 467
Description: Affinity purified rabbit polyclonal DNAL1 antibody

DNAL4 antibody
70R-36444 100 ug
EUR 294
Description: Rabbit polyclonal DNAL4 antibody

DNAL1 antibody
70R-36965 100 ug
EUR 294
Description: Rabbit Polyclonal DNAL1 antibody

DNAL1 antibody
70R-51123 100 ul
EUR 242
Description: Purified Polyclonal DNAL1 antibody

DNAL1 antibody
70R-16893 50 ul
EUR 289
Description: Rabbit polyclonal DNAL1 antibody

DNAL4 antibody
70R-16894 50 ul
EUR 289
Description: Rabbit polyclonal DNAL4 antibody

DNAL1 Antibody
24729-100ul 100ul
EUR 468

DNAL1 antibody
10R-10242 50 ul
EUR 216
Description: Mouse monoclonal DNAL1 antibody

DNAL1 Antibody
ABD4014 100 ug
EUR 525.6

DNAL1 Antibody
4733-002mg 0.02 mg
EUR 206.18
Description: DNAL1 Antibody: DNAL1 was identified as a potential candidate gene for primary ciliary dyskinesia (PCD), a genetically heterologous disorder characterized by chronic infections of the upper and lower airways that often leads to permanent lung damage, randomization of left/right body symmetry, and reduced fertility. DNAL1 is reported to be expressed solely in tissues carrying motile cilia for flagella and interacts with DNAH5, a protein that when mutated has been shown to result in PCD. It has been suggested that DNAL1 serves a regulatory function for DNAH5 activity in outer dynein arms of sperm flagella, respiratory cilia, and ependymal cilia. DNAL1 has also been recently identified as an HIV dependency factor (HDF), suggesting that DNAL1 may be an important drug target in HIV treatment. At least two isoforms of DNAL1 are known to exist.

DNAL1 Antibody
4733-01mg 0.1 mg
EUR 523.7
Description: DNAL1 Antibody: DNAL1 was identified as a potential candidate gene for primary ciliary dyskinesia (PCD), a genetically heterologous disorder characterized by chronic infections of the upper and lower airways that often leads to permanent lung damage, randomization of left/right body symmetry, and reduced fertility. DNAL1 is reported to be expressed solely in tissues carrying motile cilia for flagella and interacts with DNAH5, a protein that when mutated has been shown to result in PCD. It has been suggested that DNAL1 serves a regulatory function for DNAH5 activity in outer dynein arms of sperm flagella, respiratory cilia, and ependymal cilia. DNAL1 has also been recently identified as an HIV dependency factor (HDF), suggesting that DNAL1 may be an important drug target in HIV treatment. At least two isoforms of DNAL1 are known to exist.

DNAL1 Antibody
1-CSB-PA002222
  • Ask for price
  • Ask for price
  • 50ug
  • 100ug
Description: A polyclonal antibody against DNAL1. Recognizes DNAL1 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/40000

DNAL4 Antibody
1-CSB-PA006388
  • Ask for price
  • Ask for price
  • 50ug
  • 100ug
Description: A polyclonal antibody against DNAL4. Recognizes DNAL4 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/40000

DNAL1 Antibody
1-CSB-PA007045GA01HU
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  • Ask for price
  • 50ul
  • 150ul
Description: A polyclonal antibody against DNAL1. Recognizes DNAL1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB

DNAL4 Antibody
1-CSB-PA007046GA01HU
  • Ask for price
  • Ask for price
  • 50ul
  • 150ul
Description: A polyclonal antibody against DNAL4. Recognizes DNAL4 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB

DNAL4 Antibody
1-CSB-PA007046LA01HU
  • Ask for price
  • Ask for price
  • 50ug
  • 100ug
Description: A polyclonal antibody against DNAL4. Recognizes DNAL4 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200

dnal1 Antibody
CSB-PA724928XA01DIL-02mg 0.2mg Ask for price
Description: Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) dnal1 protein

dnal1 Antibody
CSB-PA724928XA01DIL-10mg 10mg Ask for price
Description: Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) dnal1 protein

DNAL1 Antibody
CSB-PA568072- each
EUR 402
Description: A polyclonal antibody against DNAL1. Recognizes DNAL1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

DNAL1 Antibody
CSB-PA568072-100ul 100ul
EUR 379.2
Description: A polyclonal antibody against DNAL1. Recognizes DNAL1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

DNAL1 Antibody
1-CSB-PA683815ESR1HU
  • Ask for price
  • Ask for price
  • 100ul
  • 50ul
Description: A polyclonal antibody against DNAL1. Recognizes DNAL1 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC; Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200

DNAL1 Antibody
E034660 100μg/100μl
EUR 255
Description: Available in various conjugation types.

DNAL4 Antibody
DF9470 200ul
EUR 420

DNAL4 Antibody
DF9470-100ul 100ul
EUR 168
Description: WB,IHC,IF/ICC,ELISA(peptide)

DNAL4 Antibody
DF9470-200ul 200ul
EUR 210
Description: WB,IHC,IF/ICC,ELISA(peptide)

DNAL1 Antibody
DF4014 200ul
EUR 420

DNAL1 Antibody
DF4014-100ul 100ul
EUR 168
Description: WB,IF/ICC,ELISA(peptide)

DNAL1 Antibody
DF4014-200ul 200ul
EUR 210
Description: WB,IF/ICC,ELISA(peptide)

DNAL4 Antibody
CAC08370-100ug 100ug
EUR 314

DNAL4 Antibody
CAC08370-50ug 50ug
EUR 199.2

DNAL1 Antibody
E11-15512C 100μg
EUR 225
Description: Available in various conjugation types.

DNAL4 Antibody
E11-15515C 100μg
EUR 225
Description: Available in various conjugation types.

DNAL4 Antibody
E94377 100μg
EUR 255
Description: Available in various conjugation types.

DNAL1 Antibody
E315511 100ug/200ul
EUR 295
Description: Available in various conjugation types.

DNAL1 Antibody
E38PA2804 100ul
EUR 225
Description: Available in various conjugation types.

DNAL1 Antibody
E19-4014 100μg/100μl
EUR 225
Description: Available in various conjugation types.

DNAL4 Antibody
E19-9470-1 50ug/50ul
EUR 145
Description: Available in various conjugation types.

DNAL4 Antibody
E19-9470-2 100ug/100ul
EUR 225
Description: Available in various conjugation types.

DNAL4 Antibody
E10-30478A 100ul
EUR 225
Description: Available in various conjugation types.

DNAL4 Antibody
E10-30478P 100ul
EUR 225
Description: Available in various conjugation types.

DNAL4 Antibody
E10-30479A 100ul
EUR 225
Description: Available in various conjugation types.

DNAL4 Antibody
E10-30479P 100ul
EUR 225
Description: Available in various conjugation types.

DNAL1 Antibody
GWB-MW514A 50ug Ask for price

DNAL1 antibody
MBS5310675-005mL 0.05mL
EUR 520

DNAL1 antibody
MBS5310675-5x05mL 5x0.5mL
EUR 2185

DNAL1 Antibody
MBS5315741-01mL 0.1mL
EUR 470

DNAL1 Antibody
MBS5315741-5x01mL 5x0.1mL
EUR 1955

DNAL1 Antibody
MBS1497336-005mL 0.05mL
EUR 190

DNAL1 Antibody
MBS1497336-01mL 0.1mL
EUR 270

DNAL1 Antibody
MBS1497336-5x01mL 5x0.1mL
EUR 1205

DNAL1 antibody
MBS200321-005mL 0.05mL
EUR 260

DNAL1 antibody
MBS200321-01mL 0.1mL
EUR 345

DNAL1 antibody
MBS200321-5x01mL 5x0.1mL
EUR 1300

DNAL1 Antibody
MBS150344-01mg 0.1mg
EUR 445

DNAL1 Antibody
MBS150344-5x01mg 5x0.1mg
EUR 1965

DNAL1 Antibody
MBS852820-01mg 0.1mg
EUR 305

DNAL1 Antibody
MBS852820-01mLAF405L 0.1mL(AF405L)
EUR 465

DNAL1 Antibody
MBS852820-01mLAF405S 0.1mL(AF405S)
EUR 465

DNAL1 Antibody
MBS852820-01mLAF610 0.1mL(AF610)
EUR 465

DNAL1 Antibody
MBS852820-01mLAF635 0.1mL(AF635)
EUR 465

DNAL1 Antibody
MBS7116261-005mg 0.05mg
EUR 150

DNAL1 Antibody
MBS7116261-01mg 0.1mg
EUR 190

DNAL1 Antibody
MBS7116261-5x01mg 5x0.1mg
EUR 845

DNAL4 Antibody
MBS7004764-005mg 0.05mg
EUR 190

DNAL4 Antibody
MBS7004764-01mg 0.1mg
EUR 270

DNAL4 Antibody
MBS7004764-5x01mg 5x0.1mg
EUR 1205

DNAL1 Antibody
MBS7131334-01mL 0.1mL
EUR 270

DNAL1 Antibody
MBS7131334-5x01mL 5x0.1mL
EUR 1200

DNAL4 Antibody
MBS7118850-005mg 0.05mg
EUR 150

DNAL4 Antibody
MBS7118850-01mg 0.1mg
EUR 190

DNAL4 Antibody
MBS7118850-5x01mg 5x0.1mg
EUR 845

DNAL4 Antibody
MBS8504504-01mg 0.1mg
EUR 325

DNAL4 Antibody
MBS8504504-01mLAF405L 0.1mL(AF405L)
EUR 565

DNAL4 Antibody
MBS8504504-01mLAF405S 0.1mL(AF405S)
EUR 565

DNAL4 Antibody
MBS8504504-01mLAF610 0.1mL(AF610)
EUR 565

DNAL4 Antibody
MBS8504504-01mLAF635 0.1mL(AF635)
EUR 565

DNAL4 Antibody
MBS8518481-005mg 0.05mg
EUR 235

DNAL4 Antibody
MBS8518481-01mg 0.1mg
EUR 305
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