Comprehensive genomic characterization defines human glioblastoma genes and core pathways
Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide substitutions and epigenetic modifications that drive malignant transformation. The Cancer Genome Atlas (TCGA) pilot project aims to assess the value of large-scale multi-dimensional analysis of these molecular characteristics in human cancer and to provide the data rapidly to the research community.
Here we report the interim integrative analysis of DNA copy number, gene expression and DNA methylation aberrations in 206 glioblastomas–the most common type of adult brain cancer–and nucleotide sequence aberrations in 91 of the 206 glioblastomas. This analysis provides new insights into the roles of ERBB2, NF1 and TP53, uncovers frequent mutations of the phosphatidylinositol-3-OH kinase regulatory subunit gene PIK3R1, and provides a network view of the pathways altered in the development of glioblastoma.
Rat heat shock protein 40(hSP-40)ELISA Kit |
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GA-E0527RT-48T | GenAsia Biotech | 48T | EUR 380.4 |
Rat heat shock protein 40(hSP-40)ELISA Kit |
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GA-E0527RT-96T | GenAsia Biotech | 96T | EUR 595.2 |
Rat Heat shock protein 40(Hsp-40) ELISA Kit |
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NSL0481r | Sunlong | 96 Tests | EUR 498 |
Rat heat shock protein 40(hSP-40)ELISA Kit |
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QY-E11125 | Qayee Biotechnology | 96T | EUR 433.2 |
Rat heat shock protein 40,hSP-40 ELISA Kit |
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SL0334Ra | Sunlong | - | EUR 498 |
Rat heat shock protein 40,hSP-40 ELISA Kit |
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YLA1006RA-48T | Shanghai YL Biotech | 48T | Ask for price |
Rat heat shock protein 40,hSP-40 ELISA Kit |
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YLA1006RA-96T | Shanghai YL Biotech | 96T | Ask for price |
Goat Heat shock protein 40(Hsp-40) ELISA Kit |
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NSL0606Gt | Sunlong | 96T | EUR 528 |
Human Heat Shock Protein 40,HSP-40 ELISA Kit |
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201-12-1770 | SunredBio | 96 tests | EUR 528 |
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
Mouse Heat Shock Protein 40,Hsp-40 Elisa Kit |
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EK730170 | AFG Bioscience LLC | 96 Wells | EUR 0.66 |
Human Heat Shock Protein 40(HSP-40) Elisa Kit |
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EK711018 | AFG Bioscience LLC | 96 Wells | EUR 0.13 |
Human Heat Shock Protein 40,HSP-40 ELISA Kit |
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CN-03555H1 | ChemNorm | 96T | EUR 567.6 |
Human Heat Shock Protein 40,HSP-40 ELISA Kit |
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CN-03555H2 | ChemNorm | 48T | EUR 387.6 |
Mouse Heat Shock Protein 40,Hsp-40 ELISA Kit |
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CN-02742M1 | ChemNorm | 96T | EUR 548.4 |
Mouse Heat Shock Protein 40,Hsp-40 ELISA Kit |
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CN-02742M2 | ChemNorm | 48T | EUR 367.2 |
Human Heat Shock Protein 40(HSP-40)ELISA Kit |
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GA-E1786HM-48T | GenAsia Biotech | 48T | EUR 346.8 |
Human Heat Shock Protein 40(HSP-40)ELISA Kit |
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GA-E1786HM-96T | GenAsia Biotech | 96T | EUR 559.2 |
Mouse Heat Shock Protein 40(Hsp-40)ELISA Kit |
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GA-E0316MS-48T | GenAsia Biotech | 48T | EUR 403.2 |
Mouse Heat Shock Protein 40(Hsp-40)ELISA Kit |
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GA-E0316MS-96T | GenAsia Biotech | 96T | EUR 640.8 |
Human heat shock protein 40(Hsp-40)ELISA Kit |
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NSL1987Hu | Sunlong | 96 wells | EUR 468 |
Mouse heat shock protein 40(hSP-40)ELISA Kit |
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QY-E20713 | Qayee Biotechnology | 96T | EUR 433.2 |
Human Heat Shock Protein 40(HSP-40)ELISA Kit |
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QY-E01789 | Qayee Biotechnology | 96T | EUR 433.2 |
Mouse Heat Shock Protein 40,Hsp-40 ELISA Kit |
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SL0254Mo | Sunlong | - | EUR 528 |
Human Heat Shock Protein 40,HSP-40 ELISA Kit |
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SL0828Hu | Sunlong | 96 Tests | EUR 468 |
Human Heat Shock Protein 40,HSP-40 ELISA Kit |
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YLA2764HU-48T | Shanghai YL Biotech | 48T | Ask for price |
Human Heat Shock Protein 40,HSP-40 ELISA Kit |
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YLA2764HU-96T | Shanghai YL Biotech | 96T | Ask for price |
Mouse Heat Shock Protein 40,Hsp-40 ELISA Kit |
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YLA0764MO-48T | Shanghai YL Biotech | 48T | Ask for price |
Mouse Heat Shock Protein 40,Hsp-40 ELISA Kit |
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YLA0764MO-96T | Shanghai YL Biotech | 96T | Ask for price |
Bovine Heat shock protein 40(Hsp-40) ELISA Kit |
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NSL0396Bo | Sunlong | 96 T | EUR 528 |
Canine Heat shock protein 40(Hsp-40) ELISA Kit |
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NSL0472Ca | Sunlong | 567 wells | EUR 528 |
Porcine Heat Shock Protein 40,HSP-40 Elisa Kit |
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EK751034 | AFG Bioscience LLC | 96 Wells | EUR 0.87 |
Chicken Heat Shock Protein 40,HSP-40 ELISA Kit |
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CN-00814C1 | ChemNorm | 96T | EUR 546 |
Chicken Heat Shock Protein 40,HSP-40 ELISA Kit |
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CN-00814C2 | ChemNorm | 48T | EUR 364.8 |
PoFAine Heat Shock Protein 40,HSP-40 ELISA Kit |
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CN-01299P1 | ChemNorm | 96T | EUR 548.4 |
PoFAine Heat Shock Protein 40,HSP-40 ELISA Kit |
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CN-01299P2 | ChemNorm | 48T | EUR 367.2 |
Porcine Heat shock protein 40(Hsp-40) ELISA Kit |
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NSL0508Po | Sunlong | 96T | EUR 528 |
Chicken Heat shock protein 40(Hsp-40) ELISA Kit |
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NSL0660Ch | Sunlong | 755 T | EUR 528 |
Porcine Heat Shock Protein 40,HSP-40 ELISA Kit |
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SL0051Po | Sunlong | - | EUR 528 |
Porcine Heat Shock Protein 40,HSP-40 ELISA Kit |
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YLA0293PO-48T | Shanghai YL Biotech | 48T | Ask for price |
Porcine Heat Shock Protein 40,HSP-40 ELISA Kit |
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YLA0293PO-96T | Shanghai YL Biotech | 96T | Ask for price |
Rat HSP-40(Heat Shock Protein 40) ELISA Kit |
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RE2082R-48wells | Reed Biotech | 48 wells | EUR 125.55 |
Rat HSP-40(Heat Shock Protein 40) ELISA Kit |
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RE2082R-96wells | Reed Biotech | 96 wells | EUR 179.55 |
Human HSP-40 (Heat Shock Protein 40) ELISA Kit |
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EKE61079-5x96T | Biomatik Corporation | 5x96T | EUR 2667.6 |
Human HSP-40 (Heat Shock Protein 40) ELISA Kit |
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EKE61079-96T | Biomatik Corporation | 96T | EUR 561.6 |
HSP-40 ELISA Kit| Rat Heat Shock Protein 40 ELISA Kit |
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EF017811 | Lifescience Market | 96 Tests | EUR 826.8 |
Guinea pig Heat shock protein 40(Hsp-40) ELISA Kit |
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NSL0681Gp | Sunlong | 96T | EUR 528 |
ELISA kit for Rat HSP-40 (Heat Shock Protein 40) |
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E-EL-R0477 | Elabscience Biotech | 1 plate of 96 wells | EUR 452.4 |
Description: A sandwich ELISA kit for quantitative measurement of Rat HSP-40 (Heat Shock Protein 40) in samples from Serum, Plasma, Cell supernatant |
ELISA kit for Mouse HSP-40 (Heat Shock Protein 40) |
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E-EL-M0617 | Elabscience Biotech | 1 plate of 96 wells | EUR 452.4 |
Description: A sandwich ELISA kit for quantitative measurement of Mouse HSP-40 (Heat Shock Protein 40) in samples from Serum, Plasma, Cell supernatant |
ELISA kit for Human HSP-40 (Heat Shock Protein 40) |
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E-EL-H1861 | Elabscience Biotech | 1 plate of 96 wells | EUR 452.4 |
Description: A sandwich ELISA kit for quantitative measurement of Human HSP-40 (Heat Shock Protein 40) in samples from Serum, Plasma, Cell supernatant |
Rabbit Heat Shock Protein 40 ELISA kit |
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E01A31300 | BlueGene | 96T | EUR 700 |
Description: ELISA |
Rabbit Heat Shock Protein 40 ELISA kit |
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E04H0292-192T | BlueGene | 192 tests | EUR 1524 |
Description: A sandwich ELISA for quantitative measurement of Rabbit Heat Shock Protein 40 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit Heat Shock Protein 40 ELISA kit |
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E04H0292-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A sandwich ELISA for quantitative measurement of Rabbit Heat Shock Protein 40 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit Heat Shock Protein 40 ELISA kit |
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E04H0292-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A sandwich ELISA for quantitative measurement of Rabbit Heat Shock Protein 40 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit Heat Shock Protein 40 ELISA Kit |
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ELA-E0872Rb | Lifescience Market | 96 Tests | EUR 1113.6 |
Porcine heat shock protein (HSP - 40) ELISA Kit |
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QY-E40085 | Qayee Biotechnology | 96T | EUR 480 |
Rat heat shock Protein 40, hSP-40 GENLISA ELISA |
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KLR0519 | Krishgen | 1 x 96 wells | EUR 341 |
Mouse Heat Shock Protein 40, Hsp-40 GENLISA ELISA |
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KLM0303 | Krishgen | 1 x 96 wells | EUR 341 |
Human Heat Shock Protein 40, HSP-40 GENLISA ELISA |
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KBH1769 | Krishgen | 1 x 96 wells | EUR 286 |
Chicken Heat Shock Protein 40, HSP-40 GENLISA ELISA |
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KLC0166 | Krishgen | 1 x 96 wells | EUR 341 |
Porcine Heat Shock Protein 40, HSP-40 GENLISA ELISA |
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KLP0241 | Krishgen | 1 x 96 wells | EUR 341 |
Rat heat shock protein 40,hSP-41 ELISA Kit |
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CN-01864R2 | ChemNorm | 48T | EUR 358.8 |
Rat Heat Shock Protein 40 (HSP-40) CLIA Kit |
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abx197106-96tests | Abbexa | 96 tests | EUR 990 |
Human Heat Shock Protein 40 (HSP-40) CLIA Kit |
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abx197105-96tests | Abbexa | 96 tests | EUR 990 |
Rat HSP-40 -Heat Shock Protein 40- CLIA Kit |
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E-CL-R0324-24Tests | Elabscience Biotech | 24 Tests | EUR 180 |
Description: Sandwich |
Rat HSP-40 -Heat Shock Protein 40- CLIA Kit |
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E-CL-R0324-48Tests | Elabscience Biotech | 48 Tests | EUR 546 |
Description: Sandwich |
Rat HSP-40 -Heat Shock Protein 40- CLIA Kit |
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E-CL-R0324-96Tests | Elabscience Biotech | 96 Tests | EUR 682 |
Description: Sandwich |
Rat HSP-40 -Heat Shock Protein 40- CLIA Kit |
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E-CL-R0324-96Tests10 | Elabscience Biotech | 96 Tests *10 | EUR 6820 |
Description: Sandwich |
Rat HSP-40 -Heat Shock Protein 40- CLIA Kit |
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E-CL-R0324-96Tests5 | Elabscience Biotech | 96 Tests *5 | EUR 3410 |
Description: Sandwich |
Human HSP-40 -Heat Shock Protein 40- CLIA Kit |
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E-CL-H1151-24Tests | Elabscience Biotech | 24 Tests | EUR 180 |
Description: Sandwich |
Human HSP-40 -Heat Shock Protein 40- CLIA Kit |
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E-CL-H1151-48Tests | Elabscience Biotech | 48 Tests | EUR 546 |
Description: Sandwich |
Human HSP-40 -Heat Shock Protein 40- CLIA Kit |
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E-CL-H1151-96Tests | Elabscience Biotech | 96 Tests | EUR 682 |
Description: Sandwich |
Human HSP-40 -Heat Shock Protein 40- CLIA Kit |
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E-CL-H1151-96Tests10 | Elabscience Biotech | 96 Tests *10 | EUR 6820 |
Description: Sandwich |
Human HSP-40 -Heat Shock Protein 40- CLIA Kit |
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E-CL-H1151-96Tests5 | Elabscience Biotech | 96 Tests *5 | EUR 3410 |
Description: Sandwich |
Rabbit Heat Shock Protein 20 HSP 20 ELISA kit |
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E01A31297 | BlueGene | 96T | EUR 700 |
Description: ELISA |
Rabbit Heat Shock Protein 20 HSP 20 ELISA kit |
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E04H0285-192T | BlueGene | 192 tests | EUR 1524 |
Description: A sandwich ELISA for quantitative measurement of Rabbit Heat Shock Protein 20 HSP 20 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit Heat Shock Protein 20 HSP 20 ELISA kit |
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E04H0285-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A sandwich ELISA for quantitative measurement of Rabbit Heat Shock Protein 20 HSP 20 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit Heat Shock Protein 20 HSP 20 ELISA kit |
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E04H0285-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A sandwich ELISA for quantitative measurement of Rabbit Heat Shock Protein 20 HSP 20 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
CLIA kit for Rat HSP-40 (Heat Shock Protein 40) |
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E-CL-R0324 | Elabscience Biotech | 1 plate of 96 wells | EUR 700.8 |
Description: A sandwich CLIA kit for quantitative measurement of Rat HSP-40 (Heat Shock Protein 40) in samples from Serum, Plasma, Cell supernatant |
Rabbit Heat Shock Protein 70 HSP-70 ELISA Kit |
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E01A31302 | BlueGene | 96T | EUR 700 |
Description: ELISA |
Rabbit Heat Shock Protein 70 HSP-70 ELISA kit |
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E04H0301-192T | BlueGene | 192 tests | EUR 1524 |
Description: A sandwich ELISA for quantitative measurement of Rabbit Heat Shock Protein 70 HSP-70 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit Heat Shock Protein 70 HSP-70 ELISA kit |
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E04H0301-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A sandwich ELISA for quantitative measurement of Rabbit Heat Shock Protein 70 HSP-70 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit Heat Shock Protein 70 HSP-70 ELISA kit |
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E04H0301-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A sandwich ELISA for quantitative measurement of Rabbit Heat Shock Protein 70 HSP-70 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit Heat Shock Protein 90,HSP-90 ELISA Kit |
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CN-00634R1 | ChemNorm | 96T | EUR 553.2 |
Rabbit Heat Shock Protein 90,HSP-90 ELISA Kit |
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CN-00634R2 | ChemNorm | 48T | EUR 372 |
Rabbit Heat Shock Protein 70,HSP-70 ELISA Kit |
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CN-00635R1 | ChemNorm | 96T | EUR 553.2 |
Rabbit Heat Shock Protein 70,HSP-70 ELISA Kit |
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CN-00635R2 | ChemNorm | 48T | EUR 372 |
Rabbit Heat Shock Protein 20,HSP-20 ELISA Kit |
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CN-00637R1 | ChemNorm | 96T | EUR 553.2 |
Rabbit Heat Shock Protein 20,HSP-20 ELISA Kit |
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CN-00637R2 | ChemNorm | 48T | EUR 372 |
Rabbit Heat Shock Protein 20,HSP-20 ELISA Kit |
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GA-E0087RB-48T | GenAsia Biotech | 48T | EUR 391.2 |
Rabbit Heat Shock Protein 20,HSP-20 ELISA Kit |
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GA-E0087RB-96T | GenAsia Biotech | 96T | EUR 628.8 |
Rabbit Heat Shock Protein 70,HSP-70 ELISA Kit |
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GA-E0089RB-48T | GenAsia Biotech | 48T | EUR 391.2 |
Rabbit Heat Shock Protein 70,HSP-70 ELISA Kit |
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GA-E0089RB-96T | GenAsia Biotech | 96T | EUR 628.8 |
Rabbit Heat Shock Protein 90,HSP-90 ELISA Kit |
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GA-E0090RB-48T | GenAsia Biotech | 48T | EUR 391.2 |
Rabbit Heat Shock Protein 90,HSP-90 ELISA Kit |
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GA-E0090RB-96T | GenAsia Biotech | 96T | EUR 628.8 |
Rabbit Heat Shock Protein 90,HSP-90 ELISA Kit |
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QY-E30209 | Qayee Biotechnology | 96T | EUR 448.8 |
Rabbit Heat Shock Protein 70,HSP-70 ELISA Kit |
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QY-E30210 | Qayee Biotechnology | 96T | EUR 448.8 |
Rabbit Heat Shock Protein 20,HSP-20 ELISA Kit |
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QY-E30212 | Qayee Biotechnology | 96T | EUR 448.8 |
Rabbit Heat Shock Protein 20,HSP-20 ELISA Kit |
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SL0086Rb | Sunlong | - | EUR 498 |
Rabbit Heat Shock Protein 70,HSP-70 ELISA Kit |
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SL0088Rb | Sunlong | - | EUR 498 |
Rabbit Heat Shock Protein 90,HSP-90 ELISA Kit |
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SL0089Rb | Sunlong | - | EUR 498 |
CLIA kit for Human HSP-40 (Heat Shock Protein 40) |
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E-CL-H1151 | Elabscience Biotech | 1 plate of 96 wells | EUR 700.8 |
Description: A sandwich CLIA kit for quantitative measurement of Human HSP-40 (Heat Shock Protein 40) in samples from Serum, Plasma, Cell supernatant |
Rabbit Heat shock protein HSP 90- beta, HSP90AB1 ELISA KIT |
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ELI-27130Ra | Lifescience Market | 96 Tests | EUR 1113.6 |
Rabbit Heat shock protein HSP 90- alpha, HSP90AA1 ELISA KIT |
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ELI-02919Ra | Lifescience Market | 96 Tests | EUR 1113.6 |
Rabbit Heat Shock Protein 70, HSP-70 GENLISA ELISA |
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KLX0336 | Krishgen | 1 x 96 wells | EUR 341 |
ELISA Kit for Heat Shock Protein 40 (HSP40) |
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SEA872Hu | Cloud-Clone | 96Т | EUR 630 |
ELISA Kit for Heat Shock Protein 40 (HSP40) |
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SEA872Mu | Cloud-Clone | 96Т | EUR 648 |
Human Heat Shock Protein 40 (HSP40) ELISA Kit |
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DLR-HSP40-Hu | DL Develop | 96T | EUR 422 |
Description: tissue homogenates, cell lysates or other biological fluids. |
Human Heat Shock Protein 40 (HSP40) ELISA Kit |
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DLR-HSP40-Hu-48T | DL Develop | 48T | EUR 574.8 |
Description: A sandwich quantitative ELISA assay kit for detection of Human Heat Shock Protein 40 (HSP40) in samples from tissue homogenates, cell lysates or other biological fluids. |
Human Heat Shock Protein 40 (HSP40) ELISA Kit |
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DLR-HSP40-Hu-96T | DL Develop | 96T | EUR 745.2 |
Description: A sandwich quantitative ELISA assay kit for detection of Human Heat Shock Protein 40 (HSP40) in samples from tissue homogenates, cell lysates or other biological fluids. |
Mouse Heat Shock Protein 40 (HSP40) ELISA Kit |
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DLR-HSP40-Mu | DL Develop | 96T | EUR 432 |
Description: tissue homogenates, cell lysates or other biological fluids. |
Mouse Heat Shock Protein 40 (HSP40) ELISA Kit |
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DLR-HSP40-Mu-48T | DL Develop | 48T | EUR 586.8 |
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Heat Shock Protein 40 (HSP40) in samples from tissue homogenates, cell lysates or other biological fluids. |
Mouse Heat Shock Protein 40 (HSP40) ELISA Kit |
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DLR-HSP40-Mu-96T | DL Develop | 96T | EUR 762 |
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Heat Shock Protein 40 (HSP40) in samples from tissue homogenates, cell lysates or other biological fluids. |
Human Heat Shock Protein 40 (HSP40) ELISA Kit |
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EKU04666-48T | Biomatik Corporation | 48T | EUR 500.5 |
Human Heat Shock Protein 40 (HSP40) ELISA Kit |
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EKU04666-5x96T | Biomatik Corporation | 5x96T | EUR 3396.25 |
Human Heat Shock Protein 40 (HSP40) ELISA Kit |
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EKU04666-96T | Biomatik Corporation | 96T | EUR 715 |
Mouse Heat Shock Protein 40 (HSP40) ELISA Kit |
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EKU04667-48T | Biomatik Corporation | 48T | EUR 514.08 |
Mouse Heat Shock Protein 40 (HSP40) ELISA Kit |
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EKU04667-5x96T | Biomatik Corporation | 5x96T | EUR 3488.4 |
Mouse Heat Shock Protein 40 (HSP40) ELISA Kit |
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EKU04667-96T | Biomatik Corporation | 96T | EUR 734.4 |
Human Heat Shock Protein 40 (HSP40) ELISA Kit |
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EKN45777-48T | Biomatik Corporation | 48T | EUR 341.04 |
Human Heat Shock Protein 40 (HSP40) ELISA Kit |
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EKN45777-5x96T | Biomatik Corporation | 5x96T | EUR 2314.2 |
Human Heat Shock Protein 40 (HSP40) ELISA Kit |
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EKN45777-96T | Biomatik Corporation | 96T | EUR 487.2 |
Mouse Heat Shock Protein 40 (HSP40) ELISA Kit |
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EKN45778-48T | Biomatik Corporation | 48T | EUR 350.42 |
Mouse Heat Shock Protein 40 (HSP40) ELISA Kit |
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EKN45778-5x96T | Biomatik Corporation | 5x96T | EUR 2377.85 |
Mouse Heat Shock Protein 40 (HSP40) ELISA Kit |
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EKN45778-96T | Biomatik Corporation | 96T | EUR 500.6 |
Human Heat Shock Protein 40 (HSP40) ELISA Kit |
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DL-HSP40-Hu | DL Develop | 96T | EUR 402 |
Description: tissue homogenates, cell lysates or other biological fluids. |
Mouse Heat Shock Protein 40 (HSP40) ELISA Kit |
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DL-HSP40-Mu | DL Develop | 96T | EUR 412 |
Description: tissue homogenates, cell lysates or other biological fluids. |
Mouse Heat Shock Protein 40 (HSP40) ELISA Kit |
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EK10554 | SAB | 96Т | EUR 799 |
Human Heat Shock Protein 40 (HSP40) ELISA Kit |
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EK14543 | SAB | 96Т | EUR 768 |
Mouse Heat Shock Protein 40 (HSP40) ELISA Kit |
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AE47006MO-48Tests | Abebio | 48 Tests | EUR 360 |
Description: Mouse (Mus musculus) |
Mouse Heat Shock Protein 40 (HSP40) ELISA Kit |
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AE47006MO-96Tests | Abebio | 96 Tests | EUR 680 |
Description: Mouse (Mus musculus) |
Mouse Heat Shock Protein 40 (HSP40) ELISA Kit |
|||
RK07380 | Abclonal | 96T | EUR 280 |
Human Heat Shock Protein 40 (HSP40) ELISA Kit |
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RDR-HSP40-Hu-48T | Reddot Biotech | 48T | EUR 432.39 |
Description: tissue homogenates, cell lysates and other biological fluids. |
Human Heat Shock Protein 40 (HSP40) ELISA Kit |
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RDR-HSP40-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 600 |
Human Heat Shock Protein 40 (HSP40) ELISA Kit |
|||
RDR-HSP40-Hu-96T | Reddot Biotech | 96T | EUR 617.72 |
Description: tissue homogenates, cell lysates and other biological fluids. |
Human Heat Shock Protein 40 (HSP40) ELISA Kit |
|||
RDR-HSP40-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 830.4 |
Mouse Heat Shock Protein 40 (HSP40) ELISA Kit |
|||
RDR-HSP40-Mu-48T | Reddot Biotech | 48T | EUR 443.42 |
Description: tissue homogenates, cell lysates and other biological fluids. |
Mouse Heat Shock Protein 40 (HSP40) ELISA Kit |
|||
RDR-HSP40-Mu-48Tests | Reddot Biotech | 48 Tests | EUR 613.2 |
Mouse Heat Shock Protein 40 (HSP40) ELISA Kit |
|||
RDR-HSP40-Mu-96T | Reddot Biotech | 96T | EUR 633.47 |
Description: tissue homogenates, cell lysates and other biological fluids. |
Mouse Heat Shock Protein 40 (HSP40) ELISA Kit |
|||
RDR-HSP40-Mu-96Tests | Reddot Biotech | 96 Tests | EUR 850.8 |
Human Heat Shock Protein 40 (HSP40) ELISA Kit |
|||
RD-HSP40-Hu-48T | Reddot Biotech | 48T | EUR 411.8 |
Description: tissue homogenates, cell lysates and other biological fluids. |
Furthermore, integration of mutation, DNA methylation and clinical treatment data reveals a link between MGMT promoter methylation and a hypermutator phenotype consequent to mismatch repair deficiency in treated glioblastomas, an observation with potential clinical implications. Together, these findings establish the feasibility and power of TCGA, demonstrating that it can rapidly expand knowledge of the molecular basis of cancer.
The sequence of the human genome
A 2.91-billion base pair (bp) consensus sequence of the euchromatic portion of the human genome was generated by the whole-genome shotgun sequencing method. The 14.8-billion bp DNA sequence was generated over 9 months from 27,271,853 high-quality sequence reads (5.11-fold coverage of the genome) from both ends of plasmid clones made from the DNA of five individuals. Two assembly strategies-a whole-genome assembly and a regional chromosome assembly-were used, each combining sequence data from Celera and the publicly funded genome effort.
The public data were shredded into 550-bp segments to create a 2.9-fold coverage of those genome regions that had been sequenced, without including biases inherent in the cloning and assembly procedure used by the publicly funded group. This brought the effective coverage in the assemblies to eightfold, reducing the number and size of gaps in the final assembly over what would be obtained with 5.11-fold coverage. The two assembly strategies yielded very similar results that largely agree with independent mapping data. The assemblies effectively cover the euchromatic regions of the human chromosomes.
More than 90% of the genome is in scaffold assemblies of 100,000 bp or more, and 25% of the genome is in scaffolds of 10 million bp or larger. Analysis of the genome sequence revealed 26,588 protein-encoding transcripts for which there was strong corroborating evidence and an additional approximately 12,000 computationally derived genes with mouse matches or other weak supporting evidence.
Although gene-dense clusters are obvious, almost half the genes are dispersed in low G+C sequence separated by large tracts of apparently noncoding sequence. Only 1.1% of the genome is spanned by exons, whereas 24% is in introns, with 75% of the genome being intergenic DNA. Duplications of segmental blocks, ranging in size up to chromosomal lengths, are abundant throughout the genome and reveal a complex evolutionary history. Comparative genomic analysis indicates vertebrate expansions of genes associated with neuronal function, with tissue-specific developmental regulation, and with the hemostasis and immune systems.
DNA sequence comparisons between the consensus sequence and publicly funded genome data provided locations of 2.1 million single-nucleotide polymorphisms (SNPs). A random pair of human haploid genomes differed at a rate of 1 bp per 1250 on average, but there was marked heterogeneity in the level of polymorphism across the genome. Less than 1% of all SNPs resulted in variation in proteins, but the task of determining which SNPs have functional consequences remains an open challenge.