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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

  May 25, 2021
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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide substitutions and epigenetic modifications that drive malignant transformation. The Cancer Genome Atlas (TCGA) pilot project aims to assess the value of large-scale multi-dimensional analysis of these molecular characteristics in human cancer and to provide the data rapidly to the research community.
Here we report the interim integrative analysis of DNA copy number, gene expression and DNA methylation aberrations in 206 glioblastomas–the most common type of adult brain cancer–and nucleotide sequence aberrations in 91 of the 206 glioblastomas. This analysis provides new insights into the roles of ERBB2, NF1 and TP53, uncovers frequent mutations of the phosphatidylinositol-3-OH kinase regulatory subunit gene PIK3R1, and provides a network view of the pathways altered in the development of glioblastoma.

Rabbit Heat Shock Protein 40,HSP-40 ELISA Kit
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Rabbit Heat Shock Protein 40,HSP-40 ELISA Kit
GA-E0088RB-96T 96T
EUR 628.8

Rabbit Heat Shock Protein 40,HSP-40 ELISA Kit
GA-E0088RB-96Tests 96 Tests
EUR 450

Rabbit heat shock protein 40(Hsp-40) ELISA Kit
EIA05821Rb each
EUR 520

Rabbit Heat Shock Protein 40 (HSP-40) ELISA Kit
MBS285658-10x96StripWells 10x96-Strip-Wells
EUR 6840

Rabbit Heat Shock Protein 40 (HSP-40) ELISA Kit
MBS285658-48StripWells 48-Strip-Wells
EUR 480

Rabbit Heat Shock Protein 40 (HSP-40) ELISA Kit
MBS285658-5x96StripWells 5x96-Strip-Wells
EUR 3610

Rabbit Heat Shock Protein 40 (HSP-40) ELISA Kit
MBS285658-96StripWells 96-Strip-Wells
EUR 805

Rabbit heat shock protein 40 (Hsp-40) ELISA Kit
MBS2600311-10x96StripWells 10x96-Strip-Wells
EUR 3545

Rabbit heat shock protein 40 (Hsp-40) ELISA Kit
MBS2600311-48StripWells 48-Strip-Wells
EUR 310

Rabbit heat shock protein 40 (Hsp-40) ELISA Kit
MBS2600311-5x96StripWells 5x96-Strip-Wells
EUR 1940

Rabbit heat shock protein 40 (Hsp-40) ELISA Kit
MBS2600311-96StripWells 96-Strip-Wells
EUR 475

Rabbit Heat Shock Protein 40,HSP-40 ELISA Kit
SL0087Rb -
EUR 498

Rabbit Heat Shock Protein 40,HSP-40 ELISA Kit
QY-E30211 96T
EUR 448.8

Rabbit Heat Shock Protein 40,HSP-40 ELISA Kit
CN-00636R1 96T
EUR 553.2

Rabbit Heat Shock Protein 40,HSP-40 ELISA Kit
CN-00636R2 48T
EUR 372

Rabbit HSP-40 (Heat Shock Protein 40) ELISA Kit
MBS2510100-10x96Tests 10x96Tests
EUR 4445

Rabbit HSP-40 (Heat Shock Protein 40) ELISA Kit
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EUR 280

Rabbit HSP-40 (Heat Shock Protein 40) ELISA Kit
MBS2510100-48Tests 48Tests
EUR 495

Rabbit HSP-40 (Heat Shock Protein 40) ELISA Kit
MBS2510100-5x96Tests 5x96Tests
EUR 2480

Rabbit HSP-40 (Heat Shock Protein 40) ELISA Kit
MBS2510100-96Tests 96Tests
EUR 585

Rat heat shock protein 40(hSP-40)ELISA Kit
GA-E0527RT-48T 48T
EUR 380.4

Rat heat shock protein 40(hSP-40)ELISA Kit
GA-E0527RT-48Tests 48 Tests Ask for price

Rat heat shock protein 40(hSP-40)ELISA Kit
GA-E0527RT-96T 96T
EUR 595.2

Rat heat shock protein 40(hSP-40)ELISA Kit
GA-E0527RT-96Tests 96 Tests
EUR 420

Rat heat shock protein 40(HSP-40) Elisa Kit
EK720496 96 Wells
EUR 0.57

Rat heat shock protein 40(Hsp-40) ELISA Kit
EIA05821r each
EUR 480

Rat Heat Shock Protein 40, hSP-40 ELISA Kit
MBS164395-10x96StripWells 10x96-Strip-Wells
EUR 3955

Rat Heat Shock Protein 40, hSP-40 ELISA Kit
MBS164395-48StripWells 48-Strip-Wells
EUR 305

Rat Heat Shock Protein 40, hSP-40 ELISA Kit
MBS164395-5x96StripWells 5x96-Strip-Wells
EUR 2005

Rat Heat Shock Protein 40, hSP-40 ELISA Kit
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Pig Heat Shock Protein 40 (HSP-40) ELISA Kit
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Pig Heat Shock Protein 40 (HSP-40) ELISA Kit
MBS283119-48StripWells 48-Strip-Wells
EUR 480

Pig Heat Shock Protein 40 (HSP-40) ELISA Kit
MBS283119-5x96StripWells 5x96-Strip-Wells
EUR 3610

Pig Heat Shock Protein 40 (HSP-40) ELISA Kit
MBS283119-96StripWells 96-Strip-Wells
EUR 805

Rat heat shock protein 40 (Hsp-40) ELISA Kit
MBS260312-10x96StripWells 10x96-Strip-Wells
EUR 3290

Rat heat shock protein 40 (Hsp-40) ELISA Kit
MBS260312-48StripWells 48-Strip-Wells
EUR 295

Rat heat shock protein 40 (Hsp-40) ELISA Kit
MBS260312-5x96StripWells 5x96-Strip-Wells
EUR 1800

Rat heat shock protein 40 (Hsp-40) ELISA Kit
MBS260312-96StripWells 96-Strip-Wells
EUR 450

Rat heat shock protein 40, hSP-40 ELISA Kit
MBS9303774-10x96StripWells 10x96-Strip-Wells
EUR 6725

Rat heat shock protein 40, hSP-40 ELISA Kit
MBS9303774-48StripWells 48-Strip-Wells
EUR 550

Rat heat shock protein 40, hSP-40 ELISA Kit
MBS9303774-5x96StripWells 5x96-Strip-Wells
EUR 3420

Rat heat shock protein 40, hSP-40 ELISA Kit
MBS9303774-96StripWells 96-Strip-Wells
EUR 765

Rat Heat shock protein 40(Hsp-40) ELISA Kit
NSL0481r 96 Tests
EUR 498
Description: Sandwich ELISA

Rat heat shock protein 40,hSP-40 ELISA Kit
SL0334Ra -
EUR 498

Rat heat shock protein 40,hSP-40 ELISA Kit
YLA1006RA-48T 48T Ask for price

Rat heat shock protein 40,hSP-40 ELISA Kit
YLA1006RA-96T 96T Ask for price

Rat heat shock protein 40,hSP-40 ELISA Kit
CN-01864R1 96T
EUR 538.8

Rat heat shock protein 40, hSP-40 ELISA Kit
NB-E30342 96 Well Ask for price

Goat heat shock protein 40(Hsp-40) ELISA Kit
EIA05821Go each
EUR 520

Fish Heat Shock Protein 40 (HSP-40) ELISA Kit
MBS280962-10x96StripWells 10x96-Strip-Wells
EUR 6840

Fish Heat Shock Protein 40 (HSP-40) ELISA Kit
MBS280962-48StripWells 48-Strip-Wells
EUR 480

Fish Heat Shock Protein 40 (HSP-40) ELISA Kit
MBS280962-5x96StripWells 5x96-Strip-Wells
EUR 3610

Fish Heat Shock Protein 40 (HSP-40) ELISA Kit
MBS280962-96StripWells 96-Strip-Wells
EUR 805

Goat heat shock protein 40 (Hsp-40) ELISA Kit
MBS261805-10x96StripWells 10x96-Strip-Wells
EUR 3545

Goat heat shock protein 40 (Hsp-40) ELISA Kit
MBS261805-48StripWells 48-Strip-Wells
EUR 310

Goat heat shock protein 40 (Hsp-40) ELISA Kit
MBS261805-5x96StripWells 5x96-Strip-Wells
EUR 1940

Goat heat shock protein 40 (Hsp-40) ELISA Kit
MBS261805-96StripWells 96-Strip-Wells
EUR 475

Goat Heat shock protein 40(Hsp-40) ELISA Kit
NSL0606Gt 96T
EUR 528
Description: Sandwich ELISA

Human Heat Shock Protein 40,HSP-40 ELISA Kit
201-12-1770 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Mouse Heat Shock Protein 40(Hsp-40)ELISA Kit
GA-E0316MS-48T 48T
EUR 403.2

Mouse Heat Shock Protein 40(Hsp-40)ELISA Kit
GA-E0316MS-48Tests 48 Tests Ask for price

Mouse Heat Shock Protein 40(Hsp-40)ELISA Kit
GA-E0316MS-96T 96T
EUR 640.8

Mouse Heat Shock Protein 40(Hsp-40)ELISA Kit
GA-E0316MS-96Tests 96 Tests
EUR 460

Human Heat Shock Protein 40(HSP-40)ELISA Kit
GA-E1786HM-48T 48T
EUR 346.8

Human Heat Shock Protein 40(HSP-40)ELISA Kit
GA-E1786HM-48Tests 48 Tests Ask for price

Human Heat Shock Protein 40(HSP-40)ELISA Kit
GA-E1786HM-96T 96T
EUR 559.2

Human Heat Shock Protein 40(HSP-40)ELISA Kit
GA-E1786HM-96Tests 96 Tests
EUR 388

Human Heat Shock Protein 40(HSP-40) Elisa Kit
EK711018 96 Wells
EUR 0.13

Mouse Heat Shock Protein 40,Hsp-40 Elisa Kit
EK730170 96 Wells
EUR 0.66

Human heat shock protein 40(Hsp-40) ELISA Kit
EIA05821h each
EUR 430

Mouse heat shock protein 40(Hsp-40) ELISA Kit
EIA05821m each
EUR 480

Mouse Heat Shock Protein 40, Hsp-40 ELISA Kit
MBS165276-10x96StripWells 10x96-Strip-Wells
EUR 3955

Mouse Heat Shock Protein 40, Hsp-40 ELISA Kit
MBS165276-48StripWells 48-Strip-Wells
EUR 305

Mouse Heat Shock Protein 40, Hsp-40 ELISA Kit
MBS165276-5x96StripWells 5x96-Strip-Wells
EUR 2005

Mouse Heat Shock Protein 40, Hsp-40 ELISA Kit
MBS165276-96StripWells 96-Strip-Wells
EUR 475

Human Heat Shock Protein 40, HSP-40 ELISA Kit
MBS163209-10x96StripWells 10x96-Strip-Wells
EUR 3460

Human Heat Shock Protein 40, HSP-40 ELISA Kit
MBS163209-48StripWells 48-Strip-Wells
EUR 285

Human Heat Shock Protein 40, HSP-40 ELISA Kit
MBS163209-5x96StripWells 5x96-Strip-Wells
EUR 1750

Human Heat Shock Protein 40, HSP-40 ELISA Kit
MBS163209-96StripWells 96-Strip-Wells
EUR 425

Human heat shock protein 40 (Hsp-40) ELISA Kit
MBS262312-10x96StripWells 10x96-Strip-Wells
EUR 3040

Human heat shock protein 40 (Hsp-40) ELISA Kit
MBS262312-48StripWells 48-Strip-Wells
EUR 285

Human heat shock protein 40 (Hsp-40) ELISA Kit
MBS262312-5x96StripWells 5x96-Strip-Wells
EUR 1670

Human heat shock protein 40 (Hsp-40) ELISA Kit
MBS262312-96StripWells 96-Strip-Wells
EUR 405

Mouse heat shock protein 40 (Hsp-40) ELISA Kit
MBS265826-10x96StripWells 10x96-Strip-Wells
EUR 3290

Mouse heat shock protein 40 (Hsp-40) ELISA Kit
MBS265826-48StripWells 48-Strip-Wells
EUR 295

Mouse heat shock protein 40 (Hsp-40) ELISA Kit
MBS265826-5x96StripWells 5x96-Strip-Wells
EUR 1800

Mouse heat shock protein 40 (Hsp-40) ELISA Kit
MBS265826-96StripWells 96-Strip-Wells
EUR 450

Human Heat Shock Protein 40, HSP-40 ELISA Kit
MBS9302750-10x96StripWells 10x96-Strip-Wells
EUR 6725

Human Heat Shock Protein 40, HSP-40 ELISA Kit
MBS9302750-48StripWells 48-Strip-Wells
EUR 550

Human Heat Shock Protein 40, HSP-40 ELISA Kit
MBS9302750-5x96StripWells 5x96-Strip-Wells
EUR 3420

Human Heat Shock Protein 40, HSP-40 ELISA Kit
MBS9302750-96StripWells 96-Strip-Wells
EUR 765

Mouse Heat Shock Protein 40, Hsp-40 ELISA Kit
MBS9304537-10x96StripWells 10x96-Strip-Wells
EUR 6725

Mouse Heat Shock Protein 40, Hsp-40 ELISA Kit
MBS9304537-48StripWells 48-Strip-Wells
EUR 550

Mouse Heat Shock Protein 40, Hsp-40 ELISA Kit
MBS9304537-5x96StripWells 5x96-Strip-Wells
EUR 3420

Mouse Heat Shock Protein 40, Hsp-40 ELISA Kit
MBS9304537-96StripWells 96-Strip-Wells
EUR 765

Human heat shock protein 40(Hsp-40)ELISA Kit
NSL1987Hu 96 wells
EUR 468
Description: Sandwich ELISA

Mouse Heat Shock Protein 40,Hsp-40 ELISA Kit
SL0254Mo -
EUR 528

Human Heat Shock Protein 40,HSP-40 ELISA Kit
SL0828Hu 96 Tests
EUR 468

Mouse Heat Shock Protein 40,Hsp-40 ELISA Kit
YLA0764MO-48T 48T Ask for price

Mouse Heat Shock Protein 40,Hsp-40 ELISA Kit
YLA0764MO-96T 96T Ask for price

Human Heat Shock Protein 40,HSP-40 ELISA Kit
YLA2764HU-48T 48T Ask for price

Human Heat Shock Protein 40,HSP-40 ELISA Kit
YLA2764HU-96T 96T Ask for price

Mouse Heat Shock Protein 40,Hsp-40 ELISA Kit
CN-02742M1 96T
EUR 548.4

Mouse Heat Shock Protein 40,Hsp-40 ELISA Kit
CN-02742M2 48T
EUR 367.2

Human Heat Shock Protein 40,HSP-40 ELISA Kit
CN-03555H1 96T
EUR 567.6

Human Heat Shock Protein 40,HSP-40 ELISA Kit
CN-03555H2 48T
EUR 387.6

Mouse Heat Shock Protein 40, Hsp-40 ELISA Kit
NB-E20457 96 Well Ask for price

Bovine heat shock protein 40(Hsp-40) ELISA Kit
EIA05821Bo each
EUR 520

Canine heat shock protein 40(Hsp-40) ELISA Kit
EIA05821Ca each
EUR 520

Canine heat shock protein 40 (Hsp-40) ELISA Kit
MBS2605638-10x96StripWells 10x96-Strip-Wells
EUR 3545

Canine heat shock protein 40 (Hsp-40) ELISA Kit
MBS2605638-48StripWells 48-Strip-Wells
EUR 310

Canine heat shock protein 40 (Hsp-40) ELISA Kit
MBS2605638-5x96StripWells 5x96-Strip-Wells
EUR 1940

Canine heat shock protein 40 (Hsp-40) ELISA Kit
MBS2605638-96StripWells 96-Strip-Wells
EUR 475

Bovine heat shock protein 40(Hsp-40) ELISA Kit
MBS2609290-10x96StripWells 10x96-Strip-Wells
EUR 3545

Bovine heat shock protein 40(Hsp-40) ELISA Kit
MBS2609290-48StripWells 48-Strip-Wells
EUR 310

Bovine heat shock protein 40(Hsp-40) ELISA Kit
MBS2609290-5x96StripWells 5x96-Strip-Wells
EUR 1940

Bovine heat shock protein 40(Hsp-40) ELISA Kit
MBS2609290-96StripWells 96-Strip-Wells
EUR 475

Bovine Heat shock protein 40(Hsp-40) ELISA Kit
NSL0396Bo 96 T
EUR 528
Description: Sandwich ELISA

Canine Heat shock protein 40(Hsp-40) ELISA Kit
NSL0472Ca 567 wells
EUR 528
Description: Sandwich ELISA

Porcine Heat Shock Protein 40,HSP-40 Elisa Kit
EK751034 96 Wells
EUR 0.87

Chicken heat shock protein 40(Hsp-40) ELISA Kit
EIA05821Ch each
EUR 520

Porcine heat shock protein 40(Hsp-40) ELISA Kit
EIA05821p each
EUR 520

Porcine Heat Shock Protein 40, HSP-40 ELISA Kit
MBS163395-10x96StripWells 10x96-Strip-Wells
EUR 4170

Porcine Heat Shock Protein 40, HSP-40 ELISA Kit
MBS163395-48StripWells 48-Strip-Wells
EUR 365

Porcine Heat Shock Protein 40, HSP-40 ELISA Kit
MBS163395-5x96StripWells 5x96-Strip-Wells
EUR 2115

Porcine Heat Shock Protein 40, HSP-40 ELISA Kit
MBS163395-96StripWells 96-Strip-Wells
EUR 505

Chicken Heat Shock Protein 40, HSP-40 ELISA Kit
MBS1601915-10x96StripWells 10x96-Strip-Wells
EUR 4470

Chicken Heat Shock Protein 40, HSP-40 ELISA Kit
MBS1601915-48StripWells 48-Strip-Wells
EUR 415

Chicken Heat Shock Protein 40, HSP-40 ELISA Kit
MBS1601915-5x96StripWells 5x96-Strip-Wells
EUR 2270

Chicken Heat Shock Protein 40, HSP-40 ELISA Kit
MBS1601915-96StripWells 96-Strip-Wells
EUR 540

Porcine heat shock protein 40 (Hsp-40) ELISA Kit
MBS264779-10x96StripWells 10x96-Strip-Wells
EUR 3545

Porcine heat shock protein 40 (Hsp-40) ELISA Kit
MBS264779-48StripWells 48-Strip-Wells
EUR 310

Porcine heat shock protein 40 (Hsp-40) ELISA Kit
MBS264779-5x96StripWells 5x96-Strip-Wells
EUR 1940

Porcine heat shock protein 40 (Hsp-40) ELISA Kit
MBS264779-96StripWells 96-Strip-Wells
EUR 475

Chicken heat shock protein 40 (Hsp-40) ELISA Kit
MBS264881-10x96StripWells 10x96-Strip-Wells
EUR 3545

Chicken heat shock protein 40 (Hsp-40) ELISA Kit
MBS264881-48StripWells 48-Strip-Wells
EUR 310

Chicken heat shock protein 40 (Hsp-40) ELISA Kit
MBS264881-5x96StripWells 5x96-Strip-Wells
EUR 1940

Chicken heat shock protein 40 (Hsp-40) ELISA Kit
MBS264881-96StripWells 96-Strip-Wells
EUR 475

Porcine Heat shock protein 40(Hsp-40) ELISA Kit
NSL0508Po 96T
EUR 528
Description: Sandwich ELISA

Chicken Heat shock protein 40(Hsp-40) ELISA Kit
NSL0660Ch 755 T
EUR 528
Description: Sandwich ELISA

Porcine Heat Shock Protein 40,HSP-40 ELISA Kit
SL0051Po -
EUR 528

Porcine Heat Shock Protein 40,HSP-40 ELISA Kit
YLA0293PO-48T 48T Ask for price

Porcine Heat Shock Protein 40,HSP-40 ELISA Kit
YLA0293PO-96T 96T Ask for price

Chicken Heat Shock Protein 40,HSP-40 ELISA Kit
CN-00814C1 96T
EUR 546

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Furthermore, integration of mutation, DNA methylation and clinical treatment data reveals a link between MGMT promoter methylation and a hypermutator phenotype consequent to mismatch repair deficiency in treated glioblastomas, an observation with potential clinical implications. Together, these findings establish the feasibility and power of TCGA, demonstrating that it can rapidly expand knowledge of the molecular basis of cancer.

The sequence of the human genome

A 2.91-billion base pair (bp) consensus sequence of the euchromatic portion of the human genome was generated by the whole-genome shotgun sequencing method. The 14.8-billion bp DNA sequence was generated over 9 months from 27,271,853 high-quality sequence reads (5.11-fold coverage of the genome) from both ends of plasmid clones made from the DNA of five individuals. Two assembly strategies-a whole-genome assembly and a regional chromosome assembly-were used, each combining sequence data from Celera and the publicly funded genome effort.
The public data were shredded into 550-bp segments to create a 2.9-fold coverage of those genome regions that had been sequenced, without including biases inherent in the cloning and assembly procedure used by the publicly funded group. This brought the effective coverage in the assemblies to eightfold, reducing the number and size of gaps in the final assembly over what would be obtained with 5.11-fold coverage. The two assembly strategies yielded very similar results that largely agree with independent mapping data. The assemblies effectively cover the euchromatic regions of the human chromosomes.
More than 90% of the genome is in scaffold assemblies of 100,000 bp or more, and 25% of the genome is in scaffolds of 10 million bp or larger. Analysis of the genome sequence revealed 26,588 protein-encoding transcripts for which there was strong corroborating evidence and an additional approximately 12,000 computationally derived genes with mouse matches or other weak supporting evidence.
Although gene-dense clusters are obvious, almost half the genes are dispersed in low G+C sequence separated by large tracts of apparently noncoding sequence. Only 1.1% of the genome is spanned by exons, whereas 24% is in introns, with 75% of the genome being intergenic DNA. Duplications of segmental blocks, ranging in size up to chromosomal lengths, are abundant throughout the genome and reveal a complex evolutionary history. Comparative genomic analysis indicates vertebrate expansions of genes associated with neuronal function, with tissue-specific developmental regulation, and with the hemostasis and immune systems.
DNA sequence comparisons between the consensus sequence and publicly funded genome data provided locations of 2.1 million single-nucleotide polymorphisms (SNPs). A random pair of human haploid genomes differed at a rate of 1 bp per 1250 on average, but there was marked heterogeneity in the level of polymorphism across the genome. Less than 1% of all SNPs resulted in variation in proteins, but the task of determining which SNPs have functional consequences remains an open challenge.

Arlequin (version 3.0): an integrated software package for population genetics data analysis

Arlequin ver 3.0 is a software package integrating several basic and advanced methods for population genetics data analysis, like the computation of standard genetic diversity indices, the estimation of allele and haplotype frequencies, tests of departure from linkage equilibrium, departure from selective neutrality and demographic equilibrium, estimation or parameters from past population expansions, and thorough analyses of population subdivision under the AMOVA framework.
Arlequin 3 introduces a completely new graphical interface written in C++, a more robust semantic analysis of input files, and two new methods: a Bayesian estimation of gametic phase from multi-locus genotypes, and an estimation of the parameters of an instantaneous spatial expansion from DNAsequence polymorphism. Arlequin can handle several data types like DNA sequences, microsatellite data, or standard multi-locus genotypes. A Windows version of the software is freely available on http://cmpg.unibe.ch/software/arlequin3.

Gene expression profiling predicts clinical outcome of breast cancer

Breast cancer patients with the same stage of disease can have markedly different treatment responses and overall outcome. The strongest predictors for metastases (for example, lymph node status and histological grade) fail to classify accurately breast tumours according to their clinical behaviour. Chemotherapy or hormonal therapy reduces the risk of distant metastases by approximately one-third; however, 70-80% of patients receiving this treatment would have survived without it.
None of the signatures of breast cancer gene expression reported to date allow for patient-tailored therapy strategies. Here we used DNA microarray analysis on primary breast tumours of 117 young patients, and applied supervised classification to identify a gene expression signature strongly predictive of a short interval to distant metastases (‘poor prognosis’ signature) in patients without tumour cells in local lymph nodes at diagnosis (lymph node negative).
In addition, we established a signature that identifies tumours of BRCA1 carriers. The poor prognosis signature consists of genes regulating cell cycle, invasion, metastasis and angiogenesis. This gene expression profile will outperform all currently used clinical parameters in predicting disease outcome. Our findings provide a strategy to select patients who would benefit from adjuvant therapy.

Polyclonal Dnalc4 antibody - middle region
APR15793G 0.05mg
EUR 633.6
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Dnalc4 - middle region. This antibody is tested and proven to work in the following applications:

ARP52101_P050-25UL - Dnalc4 Antibody - middle region
ARP52101_P050-25UL 25ul
EUR 99

ARP52101_P050 - Dnalc4 antibody - middle region (ARP52101_P050)
ARP52101_P050 100ul
EUR 389

Dnalc4 (GFP-tagged) - Mouse dynein, axonemal, light chain 4 (Dnalc4)
MG200362 10 µg Ask for price

Dnalc4 (Myc-DDK-tagged) - Mouse dynein, axonemal, light chain 4 (Dnalc4)
MR200362 10 µg Ask for price

Dnalc4 Peptide - middle region
MBS3235561-01mg 0.1mg
EUR 180

Dnalc4 Peptide - middle region
MBS3235561-5x01mg 5x0.1mg
EUR 730

Dnalc4 Recombinant Protein (Mouse)
RP129641 100 ug Ask for price

Dnalc4 ORF Vector (Mouse) (pORF)
ORF043215 1.0 ug DNA
EUR 607.2

Lenti ORF clone of Dnalc4 (mGFP-tagged) - Mouse dynein, axonemal, light chain 4 (Dnalc4)
MR200362L4 10 µg Ask for price

Lenti ORF clone of Dnalc4 (Myc-DDK-tagged) - Mouse dynein, axonemal, light chain 4 (Dnalc4)
MR200362L3 10 µg Ask for price

Lenti ORF particles, Dnalc4 (GFP-tagged) - Mouse dynein, axonemal, light chain 4 (Dnalc4), 200ul, >10^7 TU/mL
MR200362L4V 200 µl Ask for price

Dnalc4 3'UTR GFP Stable Cell Line
TU155288 1.0 ml Ask for price

Dnalc4 sgRNA CRISPR Lentivector set (Mouse)
K4997501 3 x 1.0 ug
EUR 406.8

Lenti ORF particles, Dnalc4 (Myc-DDK-tagged) - Mouse dynein, axonemal, light chain 4 (Dnalc4), 200ul, >10^7 TU/mL
MR200362L3V 200 µl Ask for price

Dnalc4 Protein Vector (Mouse) (pPM-C-HA)
PV172860 500 ng
EUR 723.6

Dnalc4 Protein Vector (Mouse) (pPB-C-His)
PV172858 500 ng
EUR 723.6

Dnalc4 Protein Vector (Mouse) (pPB-N-His)
PV172859 500 ng
EUR 723.6

Dnalc4 Protein Vector (Mouse) (pPM-C-His)
PV172861 500 ng
EUR 723.6

Dnalc4 3'UTR Luciferase Stable Cell Line
TU105288 1.0 ml Ask for price

Dnalc4 sgRNA CRISPR Lentivector (Mouse) (Target 1)
K4997502 1.0 ug DNA
EUR 184.8

Dnalc4 sgRNA CRISPR Lentivector (Mouse) (Target 2)
K4997503 1.0 ug DNA
EUR 184.8

Dnalc4 sgRNA CRISPR Lentivector (Mouse) (Target 3)
K4997504 1.0 ug DNA
EUR 184.8

Recombinant Mouse DNALC4 Protein, His (Fc)-Avi-tagged
DNALC4-2460M 50ug
EUR 2398.4
Description: For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.

Dnal4 (untagged) - Mouse dynein, axonemal, light chain 4 (Dnalc4), (10ug)
MC200472 10 µg Ask for price

Dnalc4 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)
K4997505 3 x 1.0 ug
EUR 451.2

Dnalc4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 1)
K4997506 1.0 ug DNA
EUR 200.4

Dnalc4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2)
K4997507 1.0 ug DNA
EUR 200.4

Dnalc4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 3)
K4997508 1.0 ug DNA
EUR 200.4

Dnalc1 Antibody - C-terminal region
MBS3215526-01mL 0.1mL
EUR 455

Dnalc1 Antibody - C-terminal region
MBS3215526-5x01mL 5x0.1mL
EUR 1995

ARP62201_P050-25UL - Dnalc1 Antibody - C-terminal region
ARP62201_P050-25UL 25ul
EUR 99

ARP62201_P050 - Dnalc1 Antibody - C-terminal region (ARP62201_P050)
ARP62201_P050 100ul
EUR 389

Dnalc4 - Mouse shRNA lentiviral particles (4 unique 29mer target-specific shRNA, 1 scramble control), 0.5 ml each, >10^7 TU/ml.
TL502994V 500 ul each Ask for price

Lenti ORF particles, Dnalc1 (GFP-tagged) - Mouse dynein, axonemal, light chain 1 (Dnalc1), 200ul, >10^7 TU/mL
MR216479L4V 200 µl Ask for price

Dnalc1 (GFP-tagged) - Mouse dynein axonemal light chain 1 (Dnalc1), (10ug)
MG216479 10 µg Ask for price

Dnalc1 (Myc-DDK-tagged) - Mouse dynein, axonemal, light chain 1 (Dnalc1)
MR216479 10 µg Ask for price

Lenti ORF particles, Dnalc1 (Myc-DDK-tagged) - Mouse dynein, axonemal, light chain 1 (Dnalc1), 200ul, >10^7 TU/mL
MR216479L3V 200 µl Ask for price

Lenti ORF clone of Dnalc1 (mGFP-tagged) - Mouse dynein, axonemal, light chain 1 (Dnalc1)
MR216479L4 10 µg Ask for price

Lenti ORF clone of Dnalc1 (Myc-DDK-tagged) - Mouse dynein, axonemal, light chain 1 (Dnalc1)
MR216479L3 10 µg Ask for price

Dnalc1 ORF Vector (Mouse) (pORF)
ORF043214 1.0 ug DNA
EUR 607.2

Dnalc1 3'UTR GFP Stable Cell Line
TU155287 1.0 ml Ask for price

Dnalc1 Peptide - C-terminal region
MBS3240429-01mg 0.1mg
EUR 180

Dnalc1 Peptide - C-terminal region
MBS3240429-5x01mg 5x0.1mg
EUR 730

Dnalc1 Protein Vector (Mouse) (pPM-C-HA)
PV172856 500 ng
EUR 723.6

Dnalc1 Protein Vector (Mouse) (pPB-C-His)
PV172854 500 ng
EUR 723.6

Dnalc1 Protein Vector (Mouse) (pPB-N-His)
PV172855 500 ng
EUR 723.6

Dnalc1 Protein Vector (Mouse) (pPM-C-His)
PV172857 500 ng
EUR 723.6

Dnalc1 Recombinant Protein (Mouse)
RP129638 100 ug Ask for price

Dnalc1 3'UTR Luciferase Stable Cell Line
TU105287 1.0 ml Ask for price

Dnalc1 sgRNA CRISPR Lentivector set (Mouse)
K4077601 3 x 1.0 ug
EUR 406.8

Dnal1 (untagged) - Mouse dynein, axonemal, light chain 1 (Dnalc1), (10ug)
MC212110 10 µg Ask for price

Dnalc1 sgRNA CRISPR Lentivector (Mouse) (Target 1)
K4077602 1.0 ug DNA
EUR 184.8

Dnalc1 sgRNA CRISPR Lentivector (Mouse) (Target 2)
K4077603 1.0 ug DNA
EUR 184.8

Dnalc1 sgRNA CRISPR Lentivector (Mouse) (Target 3)
K4077604 1.0 ug DNA
EUR 184.8

Recombinant Mouse DNALC1 Protein, His (Fc)-Avi-tagged
DNALC1-2459M 50ug
EUR 2398.4
Description: For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.

Dnalc1 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)
K4077605 3 x 1.0 ug
EUR 451.2

Dnalc1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 1)
K4077606 1.0 ug DNA
EUR 200.4

Dnalc1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2)
K4077607 1.0 ug DNA
EUR 200.4

Dnalc1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 3)
K4077608 1.0 ug DNA
EUR 200.4

Anti Bovine Leptin Antibody
111002 100 µg Ask for price

Anti Stercobilin Antibody Pab
165755 100 µg Ask for price

Anti Plant Glycan Antibody [CCRC-M95]
401030 100 µg Ask for price

Rapid Rat Antibody Isotyping Kit, 5pk
113103 5 PKS Ask for price

Rapid Human Antibody Isotyping Kit, 5pk
113101 5 PKS Ask for price

Rapid Mouse Antibody Isotyping Kit, 5pk
113102 5 PKS Ask for price

Dnalc1 - Mouse shRNA lentiviral particles (4 unique 29mer target-specific shRNA, 1 scramble control), 0.5 ml each, >10^7 TU/ml.
TL505712V 500 ul each Ask for price

Anti Mouse E3 Ubiquitin-Protein Ligase MYCBP2 Antibody, Phr1
164056 100 µg Ask for price

Anti Mouse CD226 (DNAM1) Mab [480.1]
831052 100 µg Ask for price

Anti Human CD226 (DNAM-1) Mab [11A8]
831030 100 µg Ask for price

Anti Chromohalobacter DNA Polymerase Pab
272606 100 µg Ask for price

Somatostatin Analog D-2-Nal-Cys-Tyr-D-Trp-Lys-Val-Cys-Thr-NH2.
MBS658360-1mg 1mg
EUR 610

Somatostatin Analog D-2-Nal-Cys-Tyr-D-Trp-Lys-Val-Cys-Thr-NH2.
MBS658360-5x1mg 5x1mg
EUR 2600

Somatostatin Analog D-2-Nal-Cys-Tyr-D-Trp-Lys-Val-Cys-2-NaI-NH2
MBS659446-1mg 1mg
EUR 610

Somatostatin Analog D-2-Nal-Cys-Tyr-D-Trp-Lys-Val-Cys-2-NaI-NH2
MBS659446-5x1mg 5x1mg
EUR 2600

SMARTfect DNA Immunization Adjuvant, 100x
113010 1 mL Ask for price

G418 Antibiotic Solution 1000x, Cell Culture Ready
113008 10 mL Ask for price

Puromycin Antibiotic Solution 1000x, Cell Culture Ready
113009 10 mL Ask for price

Plasmocin Mycoplama Elimination Antibiotic 1000x
113093 10 mL Ask for price

Hygromycin Antibiotic Solution 1000x, Cell Culture Ready
113011 25 mL Ask for price

Phleomycin Antibiotic Solution 1000x, Cell Culture Ready
113014 1 mL Ask for price

Blasticidin Antibiotic Solution 1000x, Cell Culture Ready
113012 25 mL Ask for price

Anti Antithrombin III Pab
165439 100 µg Ask for price

Anti 1-3-β-D-glucan Pab
165419 100 µg Ask for price

Anti Mouse IPC-Specific Antigen Mab [440c]
831039 100 µg Ask for price

Anti Plasmodium LSA1 (Liver stage antigen-1) Pab
164275 100 µg Ask for price

Anti Human Alpha 1Anti Human Chymotrypsin Pab
111444 100 µg Ask for price

Anti SERPINA1 (Alpha 1 Antichymotrypsin) Pab
272532 100 µg Ask for price

Anti H Pab
165603 100 µg Ask for price

Anti T8 Pab
165763 100 µg Ask for price

Anti KS Pab
165190 100 µg Ask for price

Anti Dog Can f1 Antbody
111525 100 µg Ask for price

Anti HE-4 Pab
165604 100 µg Ask for price

Anti HGF Pab
165607 100 µg Ask for price

Anti IL6 Pab
165622 100 µg Ask for price

Anti IL8 Pab
165623 100 µg Ask for price

Anti KBA 62 Pab
165628 100 µg Ask for price

Anti LBP Pab
165632 100 µg Ask for price

Anti MIF Pab
165660 100 µg Ask for price

Anti p16 Pab
165702 100 µg Ask for price

Anti P40 Pab
165703 100 µg Ask for price

Anti P53 Pab
165704 100 µg Ask for price

Anti TSH Pab
165799 100 µg Ask for price

Anti V5 Tag Mab
121227 100 µg Ask for price

Anti LGD 4033 Pab
163355 100 µg Ask for price

Anti A1M Pab
165425 100 µg Ask for price

Anti FIV Pab
165583 100 µg Ask for price

Anti 5HT Pab
111962 100 µg Ask for price

Anti HPV-1 Pab
165610 100 µg Ask for price

Anti H-Ras Pab
165611 100 µg Ask for price

Anti MAGE A1 Pab
165642 100 µg Ask for price

Anti MAGE A2 Pab
165644 100 µg Ask for price

Anti MAGE A3 Pab
165645 100 µg Ask for price

Anti MAGE A5 Pab
165646 100 µg Ask for price

Anti MAGE C1 Pab
165647 100 µg Ask for price

Anti MMP-2 Pab
165662 100 µg Ask for price

Anti MMP-9 Pab
165663 100 µg Ask for price

Anti Mod grf (1-29) Pab
165665 100 µg Ask for price

Anti NKX3.1 Pab
165689 100 µg Ask for price

Anti p120 Pab
165701 100 µg Ask for price

Anti SHBG Pab
165747 100 µg Ask for price

Anti TTF-1 Pab
165800 100 µg Ask for price

Anti HCV NS3 Mab
181047 100 µg Ask for price

Anti FleC Pab
134402 100 µg Ask for price

Anti TAP Tag Mab
161043 100 µg Ask for price

Anti HIV p36 Pab
163088 100 µg Ask for price

Anti HIV p41 Pab
163089 100 µg Ask for price

Anti Pig C3a Pab
163393 100 µg Ask for price

Anti Rat C3a Pab
163404 100 µg Ask for price

Anti Pig PAI Pab
164063 100 µg Ask for price

Anti G418 Mab
165144 100 µg Ask for price

Anti G418 Pab
165145 100 µg Ask for price

Anti Flag Pab
165357 100 µg Ask for price

Anti BSEP Pab
165465 100 µg Ask for price

Anti CysC Pab
165528 100 µg Ask for price

Anti D-tag Pab
165533 100 µg Ask for price

Anti DDE/DDT Pab
165536 100 µg Ask for price

Anti DOG1 Pab
165546 100 µg Ask for price

Anti Elk1 Pab
165558 100 µg Ask for price

Anti CAS9 Pab
111308 100 µg Ask for price

Anti HSV1 Pab
111395 100 µg Ask for price

Anti HSV2 Pab
111396 100 µg Ask for price

Anti CAS9 Mab
111483 100 µg Ask for price

Anti Rat CD4 Pab
111493 100 µg Ask for price

Anti Rat CD8 Pab
111495 100 µg Ask for price

Anti Dog Can f3 Pab
111526 100 µg Ask for price

Anti HIV1 Pab
111573 100 µg Ask for price

Anti HIV2 Pab
111574 100 µg Ask for price

Anti ESR1/ER Pab
111675 100 µg Ask for price

Anti TUBB Pab
111721 100 µg Ask for price

Anti Bt Cry1 Pab
111949 100 µg Ask for price

Anti Bt Cry9 Pab
111951 100 µg Ask for price

Anti CBDb Pab
111979 100 µg Ask for price
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