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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

Comprehensive genomic characterization defines human glioblastoma genes and core pathways Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide substitutions and epigenetic modifications that drive malignant transformation. The Cancer Genome Atlas (TCGA) pilot project aims to assess the value of large-scale multi-dimensional analysis of these molecular characteristics in human cancer and to provide the data […]

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Integrated genomic analyses of ovarian carcinoma

Integrated genomic analyses of ovarian carcinoma A catalogue of molecular aberrations that cause ovarian cancer is critical for developing and deploying therapies that will improve patients’ lives. The Cancer Genome Atlas project has analysed messenger RNA expression, microRNA expression, promoter methylation and DNA copy number in 489 high-grade serous ovarian adenocarcinomas and the DNA sequences of exons from coding […]

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