nordiag

GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research–an update.

GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research–an update. GenAlEx: Genetic Analysis in Excel is a cross-platform package for population genetic analyses that runs within Microsoft Excel. GenAlEx offers analysis of diploid codominant, haploid and binary genetic loci and DNA sequences. Both frequency-based (F-statistics, heterozygosity, HWE, population assignment, relatedness) and distance-based (AMOVA, […]

Read More
nordiag

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

Comprehensive genomic characterization defines human glioblastoma genes and core pathways Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide substitutions and epigenetic modifications that drive malignant transformation. The Cancer Genome Atlas (TCGA) pilot project aims to assess the value of large-scale multi-dimensional analysis of these molecular characteristics in human cancer and to provide the data […]

Read More
nordiag

MEME SUITE: tools for motif discovery and searching.

A bivalent chromatin structure marks key developmental genes in embryonic stem cells The most highly conserved noncoding elements (HCNEs) in mammalian genomes cluster within regions enriched for genes encoding developmentally important transcription factors (TFs). This suggests that HCNE-rich regions may contain key regulatory controls involved in development. We explored this by examining histone methylation in […]

Read More
nordiag

Integrated genomic analyses of ovarian carcinoma

Integrated genomic analyses of ovarian carcinoma A catalogue of molecular aberrations that cause ovarian cancer is critical for developing and deploying therapies that will improve patients’ lives. The Cancer Genome Atlas project has analysed messenger RNA expression, microRNA expression, promoter methylation and DNA copy number in 489 high-grade serous ovarian adenocarcinomas and the DNA sequences of exons from coding […]

Read More