A framework for variation discovery and genotyping using next-generation DNA sequencing data.
Recent advances in sequencing technology make it possible to comprehensively catalog genetic variation in population samples, creating a foundation for understanding human disease, ancestry and evolution. The amounts of raw data produced are prodigious, and many computational steps are required to translate this output into high-quality variant calls. We present a unified analytic framework to discover and genotype variation among multiple samples simultaneously that achieves sensitive and specific results across five sequencing technologies and three distinct, canonical experimental designs.
Our process includes (i) initial read mapping; (ii) local realignment around indels; (iii) base quality score recalibration; (iv) SNP discovery and genotyping to find all potential variants; and (v) machine learning to separate true segregating variation from machine artifacts common to next-generation sequencing technologies. We here discuss the application of these tools, instantiated in the Genome Analysis Toolkit, to deep whole-genome, whole-exome capture and multi-sample low-pass (∼4×) 1000 Genomes Project datasets.
Green RNA Lysis Kit 50 |
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GREENE1-RNA | Next Advance | 50pack | EUR 216 |
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 50, 1.5mL Eppendorf Safe-Lock tubes prefilled with beads. RNase free. |
Green RNA Lysis Kit 250 |
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GREENE5-RNA | Next Advance | 250pack | EUR 685.2 |
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 250, 1.5mL Eppendorf Safe-Lock tubes prefilled with beads. RNase free. |
Pink RNA Lysis Kit 50 |
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PINKE1-RNA | Next Advance | 50pack | EUR 213.6 |
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 50, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free. |
Pink RNA Lysis Kit 250 |
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PINKE5-RNA | Next Advance | 250pack | EUR 673.2 |
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 250, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free. |
Red RNA Lysis Kit 50 |
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REDE1-RNA | Next Advance | 50pack | EUR 230.4 |
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 50, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free. |
Red RNA Lysis Kit 250 |
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REDE5-RNA | Next Advance | 250pack | EUR 746.4 |
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 250, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free. |
YELLOW RNA Lysis Kit 50 |
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YELLOWE1-RNA | Next Advance | 50pack | EUR 230.4 |
Description: Bead lysis kits for the homogenization of small cell suspensions (ex - E. coli). Pack of 50, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free. |
YELLOW RNA Lysis Kit 250 |
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YELLOWE5-RNA | Next Advance | 250pack | EUR 748.8 |
Description: Bead lysis kits for the homogenization of small cell suspensions (ex - E. coli). Pack of 250, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free. |
5E Navy RNA Lysis Kit 100 |
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NAVY5E100-RNA | Next Advance | 100pack | EUR 543.6 |
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 100, 5mL Eppendorf Safe-Lock tubes prefilled with stainless steel beads. RNase free. |
5E Navy RNA Lysis Kit 20 |
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NAVY5E20-RNA | Next Advance | 20pack | EUR 183.6 |
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 20, 5mL Eppendorf Safe-Lock tubes prefilled with stainless steel beads. RNase free. |
Navy RINO RNA Lysis Kit 50 |
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NAVYR1-RNA | Next Advance | 50pack | EUR 242.4 |
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 50, 1.5mL RINO screw-cap tubes prefilled with stainless steel beads. RNase free. |
Navy RINO RNA Lysis Kit 250 |
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NAVYR5-RNA | Next Advance | 250pack | EUR 799.2 |
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 250, 1.5mL RINO screw-cap tubes prefilled with stainless steel beads. RNase free. |
5E GREEN RNA Lysis Kit 100 |
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GREEN5E100-RNA | Next Advance | 100pack | EUR 463.2 |
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 1000, 5mL Eppendorf Safe-Lock tubes prefilled with beads. RNase free. |
5E GREEN RNA Lysis Kit 20 |
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GREEN5E20-RNA | Next Advance | 20pack | EUR 165.6 |
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 20, 5mL Eppendorf Safe-Lock tubes prefilled with beads. RNase free. |
Green RINO RNA Lysis Kit 50 |
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GREENR1-RNA | Next Advance | 50pack | EUR 220.8 |
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 50, 1.5mL RINO screw-cap tubes prefilled with beads. RNase free. |
Green RINO RNA Lysis Kit 250 |
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GREENR5-RNA | Next Advance | 250pack | EUR 704.4 |
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 250, 1.5mL RINO screw-cap tubes prefilled with beads. RNase free. |
5E PINK RNA Lysis Kit 100 |
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PINK5E100-RNA | Next Advance | 100pack | EUR 456 |
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 100, 5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free. |
5E PINK RNA Lysis Kit 20 |
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PINK5E20-RNA | Next Advance | 20pack | EUR 163.2 |
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 20, 5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free. |
Pink RINO RNA Lysis Kit 50 |
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PINKR1-RNA | Next Advance | 50pack | EUR 217.2 |
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 50, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free. |
Pink RINO RNA Lysis Kit 250 |
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PINKR5-RNA | Next Advance | 250pack | EUR 691.2 |
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 250, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free. |
5E RED RNA Lysis Kit 100 |
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RED5E100-RNA | Next Advance | 100pack | EUR 514.8 |
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 100, 5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free. |
5E RED RNA Lysis Kit 20 |
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RED5E20-RNA | Next Advance | 20pack | EUR 177.6 |
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 20, 5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free. |
Red RINO RNA Lysis Kit 50 |
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REDR1-RNA | Next Advance | 50pack | EUR 234 |
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 50, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free. |
Red RINO RNA Lysis Kit 250 |
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REDR5-RNA | Next Advance | 250pack | EUR 765.6 |
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 250, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free. |
YELLOW RINO RNA Lysis Kit 50 |
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YELLOWR1-RNA | Next Advance | 50pack | EUR 238.8 |
Description: Bead lysis kits for the homogenization of small cell suspensions (ex - E. coli). Pack of 50, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free. |
YELLOW RINO RNA Lysis Kit 250 |
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YELLOWR5-RNA | Next Advance | 250pack | EUR 787.2 |
Description: Bead lysis kits for the homogenization of small cell suspensions (ex - E. coli). Pack of 250, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free. |
Exosomal RNA Extraction Kit |
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P200R,-part-of-P200 | 101Bio | - | Ask for price |
100 BP DNA LADDER, 500UL PER KIT |
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M-DNA-100BP | CORNING | 1/pk | EUR 87.6 |
Description: Bioscience Mol Bio; DNA Ladder |
1 KB DNA LADDER, 500UL PER KIT |
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M-DNA-1KB | CORNING | 1/pk | EUR 84 |
Description: Bioscience Mol Bio; DNA Ladder |
Custom production of antibodies in 5 Rats using customer supplied antigen (std 63 days protocol) |
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RAT-5 | Alpha Diagnostics | 1 | EUR 1365.6 |
Dr. P Kit-Isolation of RNA, DNA and Protein from the same piece of tissue simultaneously |
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K2021010 | Biochain | 1 kit | EUR 506.4 |
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. |
Set of 8 Sulfur Oil Standards in Base Oil 20 100 grams |
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DSS8-SET | Scientific Laboratory Supplies | EACH | EUR 636.12 |
Kin17 DNA And RNA Binding Protein (KIN) Antibody |
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20-abx113374 | Abbexa |
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Kin17 DNA And RNA Binding Protein (KIN) Protein |
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20-abx260971 | Abbexa |
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Kin17 DNA And RNA Binding Protein (KIN) Antibody |
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abx234575-100ug | Abbexa | 100 ug | EUR 610.8 |
Cross match determination (FCXM) |
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FCXM-100T | ImmunoStep | 100 test | EUR 806.18 |
Cross match determination (FCXM) |
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FCXM-25T | ImmunoStep | 25 test | EUR 412.04 |
Cross match determination (FCXM) |
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FCXMPU | ImmunoStep | 0,5 mg | EUR 620.04 |
Set of 8 Sulfur in Oil Standards in no.2 DieselFuel 100 grams |
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SDFS-SET | Scientific Laboratory Supplies | EACH | EUR 657.78 |
ICP-MS Set of 2 Memory Test Solutions |
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CL-MEM-SET | Scientific Laboratory Supplies | EACH | EUR 467.4 |
Groundwater and Wastewater Pollution Control Check Standard (includes WP-11 and MN-4) |
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AM-SET | Scientific Laboratory Supplies | EACH | EUR 355.68 |
Human Brain Genomic DNA |
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X11001-1 | EpiGentek | 10 ul | EUR 77 |
Human Brain Genomic DNA |
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X11001 | EpiGentek |
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Groundwater and Wastewater Pollution Control Check Standard (includes WP-15N WP-3 and MN-6) |
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TM-SET | Scientific Laboratory Supplies | EACH | EUR 417.24 |
Total RNA from Rat Normal Tissue: Brain |
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R1434035-50 | Biochain | 50 ug | EUR 182.4 |
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
Viral DNA / RNA Kit |
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20-abx098090 | Abbexa |
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Viral DNA / RNA Kit |
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abx098872-50rxns | Abbexa | 50 rxns | EUR 444 |
DNA / RNA Damage Antibody |
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abx440040-100ug | Abbexa | 100 ug | EUR 661.2 |
DNA / RNA Damage Antibody |
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abx442569-100ug | Abbexa | 100 ug | EUR 661.2 |
DNA / RNA Damage Antibody |
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abx442850-100ug | Abbexa | 100 ug | EUR 661.2 |
DNA / RNA Damage Antibody |
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abx443130-100ug | Abbexa | 100 ug | EUR 661.2 |
DNA / RNA Damage Antibody |
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abx443410-100ug | Abbexa | 100 ug | EUR 644.4 |
DNA / RNA Damage Antibody |
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abx443691-100ug | Abbexa | 100 ug | EUR 678 |
DNA / RNA Damage Antibody |
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abx443972-100ug | Abbexa | 100 ug | EUR 661.2 |
DNA / RNA Damage Antibody |
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abx444253-100ug | Abbexa | 100 ug | EUR 661.2 |
DNA / RNA Damage Antibody |
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abx444534-100ug | Abbexa | 100 ug | EUR 661.2 |
DNA / RNA Damage Antibody |
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20-abx444884 | Abbexa |
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DNA / RNA Damage Antibody |
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abx440321-100ug | Abbexa | 100 ug | EUR 661.2 |
DNA / RNA Damage Antibody |
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abx440602-100ug | Abbexa | 100 ug | EUR 661.2 |
DNA / RNA Damage Antibody |
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abx440883-100ug | Abbexa | 100 ug | EUR 661.2 |
DNA / RNA Damage Antibody |
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abx441164-100ug | Abbexa | 100 ug | EUR 661.2 |
DNA / RNA Damage Antibody |
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abx441445-100ug | Abbexa | 100 ug | EUR 661.2 |
DNA / RNA Damage Antibody |
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abx441726-100ug | Abbexa | 100 ug | EUR 661.2 |
DNA / RNA Damage Antibody |
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abx442007-100ug | Abbexa | 100 ug | EUR 661.2 |
DNA / RNA Damage Antibody |
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abx442288-100ug | Abbexa | 100 ug | EUR 661.2 |
EZBlock? Universal Protease and Phosphatase Inhibitor Cocktail |
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K283-set | Biovision | EUR 744 |
Human Kin17 DNA And RNA Binding Protein (KIN) ELISA Kit |
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abx388159-96tests | Abbexa | 96 tests | EUR 1093.2 |
MAX LIFE Gene Analyzer - Fluorometer for DNA, RNA and Protein |
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H100 | GeneOn | 1 pcs | Ask for price |
Genomic DNA from Rat Normal Tissue: Brain |
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D1434035 | Biochain | 100 ug | EUR 338.4 |
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
EZCell? Cell Stimulation and Protein Transport Inhibitor Cocktail (500X) |
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K931-set | Biovision | EUR 444 |
EZBlock? Universal Protease and Phosphatase Inhibitor Cocktail , EDTA-Free |
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K284-set | Biovision | EUR 751.2 |
Nanosoft Clipping Tool, Set of 4 grid clipping tools with C-Clip Bottoming tool and Tool Rack |
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M-CEM-NS-CLT-Set | MiTeGen | 1 UNIT | EUR 900 |
Description: Nanosoft Clipping Tool, Set of 4 grid clipping tools with C-Clip Bottoming tool and Tool Rack |
Match cell/stpr QS/GLP10mm 3.5ml |
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CEL2052 | Scientific Laboratory Supplies | 1PR | EUR 363.66 |
Match cell/lid QS LP10mm 1.4ml |
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CEL2120 | Scientific Laboratory Supplies | 1PR | EUR 274.74 |
ELISA Microplate Washer Automated (#MPW-30) bottle set (3 bottles and cap assembly) |
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MPW-30-SET | Alpha Diagnostics | 1 | EUR 489.6 |
Total RNA from Rat Normal Tissue: Brain, cerebellum |
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R1434039-50 | Biochain | 50 ug | EUR 182.4 |
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
ICP Environmental EPA Set |
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EPA-SET | Scientific Laboratory Supplies | EACH | EUR 1512.78 |
BenzNuclease DNA and RNA Nuclease (Ultra Pure, Protease Free) Recombinant Protein |
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11-552 | ProSci | 50KU | EUR 481.2 |
Description: BenzNuclease DNA and RNA Nuclease (Ultra Pure, Protease Free) Recombinant Protein |
Human DNA-directed RNA polymerases I and III subunit RPAC2 (POLR1D) |
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1-CSB-EP897095HU | Cusabio |
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Description: Recombinant Human DNA-directed RNA polymerases I and III subunit RPAC2(POLR1D) expressed in E.coli |
NUCLEAZOR, DNA & RNA Decontaminant Spray |
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N5000-025 | GenDepot | 250 ml | EUR 162 |
Human DNA-directed DNA/RNA polymerase mu (POLM) |
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1-CSB-EP889065HU | Cusabio |
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Description: Recombinant Human DNA-directed DNA/RNA polymerase mu(POLM) expressed in E.coli |
Human DNA-directed DNA/RNA polymerase mu (POLM) |
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1-CSB-BP889065HU | Cusabio |
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Description: Recombinant Human DNA-directed DNA/RNA polymerase mu(POLM) expressed in Baculovirus |
Human DNA-directed DNA/RNA polymerase mu (POLM) |
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1-CSB-YP889065HU | Cusabio |
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Description: Recombinant Human DNA-directed DNA/RNA polymerase mu(POLM) expressed in Yeast |
Recombinant human DNA-directed DNA/RNA polymerase mu |
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P2815 | FN Test | 100ug | Ask for price |
Description: Recombinant protein for human DNA-directed DNA/RNA polymerase mu |
Total RNA from Alzheimer's Disease: Brain |
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R1236035Alz-50 | Biochain | 50 ug | EUR 421.2 |
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
1 each of 6.5 mm, 12 mm, 16 mm, 20 mm heights |
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EZStage-Set | MiTeGen | 4 UNITS | EUR 340 |
Description: 1 each of 6.5 mm, 12 mm, 16 mm, 20 mm heights |
US EPA Method 200.7 (Rev.3.3) and SW-846 Method 6010 (3rd ed.) |
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MIXSTD-SET | Scientific Laboratory Supplies | EACH | EUR 595.08 |
Brain and Acute Leukemia, Cytoplamatic |
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PR27238 | Neuromics | 2 ug | EUR 229.2 |
DNA-Directed RNA Polymerases I, II, And III Subunit RPABC3 (RPAB3) Antibody |
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20-abx149876 | Abbexa |
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DNA-Directed RNA Polymerases I, II, And III Subunit RPABC4 (POLR2K) Antibody |
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20-abx135780 | Abbexa |
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DNA-Directed RNA Polymerases I, II, And III Subunit RPABC4 (POLR2K) Antibody |
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20-abx007835 | Abbexa |
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DNA-Directed RNA Polymerases I, II, And III Subunit RPABC1 (POLR2E) Antibody |
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20-abx001458 | Abbexa |
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DNA-Directed RNA Polymerases I, II, And III Subunit RPABC1 (POLR2E) Antibody |
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20-abx121663 | Abbexa |
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DNA-Directed RNA Polymerases I, II, And III Subunit RPABC1 (RPAB1) Antibody |
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20-abx119102 | Abbexa |
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DNA-Directed RNA Polymerases I, II, And III Subunit RPABC1 (POLR2E) Antibody |
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20-abx114604 | Abbexa |
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DNA-Directed RNA Polymerases I, II, And III Subunit RPABC1 (POLR2E) Antibody |
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abx028042-400ul | Abbexa | 400 ul | EUR 627.6 |
DNA-Directed RNA Polymerases I, II, And III Subunit RPABC1 (POLR2E) Antibody |
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abx028042-80l | Abbexa | 80 µl | EUR 343.2 |
DNA-Directed RNA Polymerases I, II, And III Subunit RPABC1 (POLR2E) Antibody |
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abx036186-100ug | Abbexa | 100 ug | EUR 469.2 |
DNA-Directed RNA Polymerases I, II, And III Subunit RPABC2 (RPAB2) Antibody |
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20-abx217855 | Abbexa |
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DNA-Directed RNA Polymerases I, II, And III Subunit RPABC4 (RPAB4) Antibody |
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20-abx217857 | Abbexa |
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DNA-Directed RNA Polymerases I, II, And III Subunit RPABC1 (POLR2E) Antibody |
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20-abx304890 | Abbexa |
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DNA-Directed RNA Polymerases I, II, And III Subunit RPABC4 (POLR2K) Antibody |
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20-abx304897 | Abbexa |
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StemBoost? YPAC Cocktail Set (1000X), Sterile-Filtered |
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K871-set | Biovision | EUR 1149.6 |
ELISA kit for Rat DNA-directed RNA polymerases I, II, and III subunit RPABC1 (POLR2E) |
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KTE100871-48T | Abbkine | 48T | EUR 398.4 |
Description: Quantitative sandwich ELISA for measuring Rat DNA-directed RNA polymerases I, II, and III subunit RPABC1 (POLR2E) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Rat DNA-directed RNA polymerases I, II, and III subunit RPABC1 (POLR2E) |
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KTE100871-5platesof96wells | Abbkine | 5 plates of 96 wells | EUR 2538 |
Description: Quantitative sandwich ELISA for measuring Rat DNA-directed RNA polymerases I, II, and III subunit RPABC1 (POLR2E) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Rat DNA-directed RNA polymerases I, II, and III subunit RPABC1 (POLR2E) |
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KTE100871-96T | Abbkine | 96T | EUR 646.8 |
Description: Quantitative sandwich ELISA for measuring Rat DNA-directed RNA polymerases I, II, and III subunit RPABC1 (POLR2E) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ISOLATE II RNA/DNA/Protein Kit |
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BIO-52085 | Bioline | 50 preps | Ask for price |
ISOLATE II RNA/DNA/Protein Kit |
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BIO-52085/S | Bioline | Sample | Ask for price |
ISOLATE II FFPE RNA/DNA Kit |
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BIO-52087 | Bioline | 50 Preps | Ask for price |
RNA/DNA Purification Kit (Magnetic Bead) |
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DA0623 | Daan Gene | 32 test/kit | Ask for price |
96-well Viral DNA/RNA Kit |
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K1417-1 | Biovision | EUR 470.4 |
96-well Viral DNA/RNA Kit |
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K1417-4 | Biovision | EUR 1227.6 |
Silicon Column for DNA/RNA Extraction |
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GR238011 | Genorise Scientific | Pack of 100 | EUR 170.4 |
Monoclonal antibody for DNA/RNA Damage |
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SMC-155C | Stressmarq | 0.025mg | EUR 228 |
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Dog | Rabbit DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is not conjugated. |
Monoclonal antibody for DNA/RNA Damage |
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SMC-155D | Stressmarq | 0.1mg | EUR 398.4 |
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Dog | Rabbit DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is not conjugated. |
Monoclonal antibody for DNA/RNA Damage |
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SMC-155D-A390 | Stressmarq | 0.1mg | EUR 454.8 |
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Dog | Rabbit DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 390. |
Monoclonal antibody for DNA/RNA Damage |
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SMC-155D-A488 | Stressmarq | 0.1mg | EUR 453.6 |
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 488. |
Monoclonal antibody for DNA/RNA Damage |
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SMC-155D-A565 | Stressmarq | 0.1mg | EUR 453.6 |
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 565. |
Monoclonal antibody for DNA/RNA Damage |
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SMC-155D-A594 | Stressmarq | 0.1mg | EUR 453.6 |
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 594. |
Monoclonal antibody for DNA/RNA Damage |
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SMC-155D-A633 | Stressmarq | 0.1mg | EUR 453.6 |
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 633. |
Monoclonal antibody for DNA/RNA Damage |
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SMC-155D-A655 | Stressmarq | 0.1mg | EUR 453.6 |
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 655. |
Monoclonal antibody for DNA/RNA Damage |
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SMC-155D-A680 | Stressmarq | 0.1mg | EUR 453.6 |
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 680. |
Monoclonal antibody for DNA/RNA Damage |
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SMC-155D-A700 | Stressmarq | 0.1mg | EUR 453.6 |
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 700. |
Monoclonal antibody for DNA/RNA Damage |
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SMC-155D-ALP | Stressmarq | 0.1mg | EUR 446.4 |
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Alkaline Phosphatase. |
Monoclonal antibody for DNA/RNA Damage |
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SMC-155D-APC | Stressmarq | 0.1mg | EUR 452.4 |
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with APC. |
The 1982 revised criteria for the classification of systemic lupus erythematosus
The 1971 preliminary criteria for the classification of systemic lupus erythematosus (SLE) were revised and updated to incorporate new immunologic knowledge and improve disease classification. The 1982 revised criteria include fluorescence antinuclear antibody and antibody to native DNA and Sm antigen. Some criteria involving the same organ systems were aggregated into single criteria.
Raynaud’s phenomenon and alopecia were not included in the 1982 revised criteria because of low sensitivity and specificity. The new criteria were 96% sensitive and 96% specific when tested with SLE and control patient data gathered from 18 participating clinics. When compared with the 1971 criteria, the 1982 revised criteria showed gains in sensitivity and specificity.