A framework for variation discovery and genotyping using next-generation DNA sequencing data.
Recent advances in sequencing technology make it possible to comprehensively catalog genetic variation in population samples, creating a foundation for understanding human disease, ancestry and evolution. The amounts of raw data produced are prodigious, and many computational steps are required to translate this output into high-quality variant calls. We present a unified analytic framework to discover and genotype variation among multiple samples simultaneously that achieves sensitive and specific results across five sequencing technologies and three distinct, canonical experimental designs.
Our process includes (i) initial read mapping; (ii) local realignment around indels; (iii) base quality score recalibration; (iv) SNP discovery and genotyping to find all potential variants; and (v) machine learning to separate true segregating variation from machine artifacts common to next-generation sequencing technologies. We here discuss the application of these tools, instantiated in the Genome Analysis Toolkit, to deep whole-genome, whole-exome capture and multi-sample low-pass (∼4×) 1000 Genomes Project datasets.
![]() Red RNA Lysis Kit 250 |
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REDE5-RNA | Next Advance | 250pack | EUR 622 |
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 250, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free. |
![]() YELLOW RNA Lysis Kit 50 |
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YELLOWE1-RNA | Next Advance | 50pack | EUR 192 |
Description: Bead lysis kits for the homogenization of small cell suspensions (ex - E. coli). Pack of 50, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free. |
![]() YELLOW RNA Lysis Kit 250 |
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YELLOWE5-RNA | Next Advance | 250pack | EUR 624 |
Description: Bead lysis kits for the homogenization of small cell suspensions (ex - E. coli). Pack of 250, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free. |
![]() 5E GREEN RNA Lysis Kit 100 |
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GREEN5E100-RNA | Next Advance | 100pack | EUR 386 |
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 1000, 5mL Eppendorf Safe-Lock tubes prefilled with beads. RNase free. |
![]() 5E GREEN RNA Lysis Kit 20 |
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GREEN5E20-RNA | Next Advance | 20pack | EUR 138 |
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 20, 5mL Eppendorf Safe-Lock tubes prefilled with beads. RNase free. |
![]() Green RINO RNA Lysis Kit 50 |
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GREENR1-RNA | Next Advance | 50pack | EUR 184 |
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 50, 1.5mL RINO screw-cap tubes prefilled with beads. RNase free. |
![]() Green RINO RNA Lysis Kit 250 |
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GREENR5-RNA | Next Advance | 250pack | EUR 587 |
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 250, 1.5mL RINO screw-cap tubes prefilled with beads. RNase free. |
![]() 5E PINK RNA Lysis Kit 100 |
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PINK5E100-RNA | Next Advance | 100pack | EUR 380 |
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 100, 5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free. |
![]() 5E PINK RNA Lysis Kit 20 |
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PINK5E20-RNA | Next Advance | 20pack | EUR 136 |
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 20, 5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free. |
![]() Pink RINO RNA Lysis Kit 50 |
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PINKR1-RNA | Next Advance | 50pack | EUR 181 |
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 50, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free. |
![]() Pink RINO RNA Lysis Kit 250 |
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PINKR5-RNA | Next Advance | 250pack | EUR 576 |
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 250, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free. |
![]() Navy RINO RNA Lysis Kit 250 |
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NAVYR5-RNA | Next Advance | 250pack | EUR 666 |
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 250, 1.5mL RINO screw-cap tubes prefilled with stainless steel beads. RNase free. |
![]() 5E Navy RNA Lysis Kit 100 |
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NAVY5E100-RNA | Next Advance | 100pack | EUR 453 |
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 100, 5mL Eppendorf Safe-Lock tubes prefilled with stainless steel beads. RNase free. |
![]() 5E Navy RNA Lysis Kit 20 |
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NAVY5E20-RNA | Next Advance | 20pack | EUR 153 |
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 20, 5mL Eppendorf Safe-Lock tubes prefilled with stainless steel beads. RNase free. |
![]() Navy RINO RNA Lysis Kit 50 |
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NAVYR1-RNA | Next Advance | 50pack | EUR 202 |
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 50, 1.5mL RINO screw-cap tubes prefilled with stainless steel beads. RNase free. |
![]() 5E RED RNA Lysis Kit 100 |
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RED5E100-RNA | Next Advance | 100pack | EUR 429 |
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 100, 5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free. |
![]() 5E RED RNA Lysis Kit 20 |
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RED5E20-RNA | Next Advance | 20pack | EUR 148 |
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 20, 5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free. |
![]() Red RINO RNA Lysis Kit 50 |
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REDR1-RNA | Next Advance | 50pack | EUR 195 |
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 50, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free. |
![]() Red RINO RNA Lysis Kit 250 |
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REDR5-RNA | Next Advance | 250pack | EUR 638 |
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 250, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free. |
![]() YELLOW RINO RNA Lysis Kit 50 |
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YELLOWR1-RNA | Next Advance | 50pack | EUR 199 |
Description: Bead lysis kits for the homogenization of small cell suspensions (ex - E. coli). Pack of 50, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free. |
![]() YELLOW RINO RNA Lysis Kit 250 |
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YELLOWR5-RNA | Next Advance | 250pack | EUR 656 |
Description: Bead lysis kits for the homogenization of small cell suspensions (ex - E. coli). Pack of 250, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free. |
![]() Custom production of antibodies in 5 Rats using customer supplied antigen (std 63 days protocol) |
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RAT-5 | Alpha Diagnostics | 1 | EUR 1138 |
![]() Exosomal RNA Extraction Kit |
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P200R,-part-of-P200 | 101Bio | - | Ask for price |
![]() Cross match determination (FCXM) |
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FCXM-100T | ImmunoStep | 100 test | EUR 671.82 |
![]() Cross match determination (FCXM) |
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FCXM-25T | ImmunoStep | 25 test | EUR 343.37 |
![]() Cross match determination (FCXM) |
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FCXMPU | ImmunoStep | 0,5 mg | EUR 516.7 |
![]() Kin17 DNA And RNA Binding Protein (KIN) Antibody |
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20-abx113374 | Abbexa |
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![]() Kin17 DNA And RNA Binding Protein (KIN) Protein |
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20-abx260971 | Abbexa |
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![]() Kin17 DNA And RNA Binding Protein (KIN) Antibody |
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abx234575-100ug | Abbexa | 100 ug | EUR 509 |
![]() 100 BP DNA LADDER, 500UL PER KIT |
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M-DNA-100BP | CORNING | 1/pk | EUR 73 |
Description: Bioscience Mol Bio; DNA Ladder |
![]() 1 KB DNA LADDER, 500UL PER KIT |
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M-DNA-1KB | CORNING | 1/pk | EUR 70 |
Description: Bioscience Mol Bio; DNA Ladder |
![]() Dr. P Kit-Isolation of RNA, DNA and Protein from the same piece of tissue simultaneously |
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K2021010 | Biochain | 1 kit | EUR 422 |
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. |
![]() Human Brain Genomic DNA |
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X11001 | EpiGentek | 10 µg | Ask for price |
Description: kits suitable for this type of research |
![]() EZBlock? Universal Protease and Phosphatase Inhibitor Cocktail |
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K283-set | Biovision | EUR 620 |
![]() Total RNA from Rat Normal Tissue: Brain |
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R1434035-50 | Biochain | 50 ug | EUR 152 |
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
![]() Viral DNA / RNA Kit |
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20-abx098090 | Abbexa |
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![]() Viral DNA / RNA Kit |
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abx098872-50rxns | Abbexa | 50 rxns | EUR 370 |
![]() DNA / RNA Damage Antibody |
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abx440040-100ug | Abbexa | 100 ug | EUR 551 |
![]() DNA / RNA Damage Antibody |
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abx440321-100ug | Abbexa | 100 ug | EUR 551 |
![]() DNA / RNA Damage Antibody |
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abx440602-100ug | Abbexa | 100 ug | EUR 551 |
![]() DNA / RNA Damage Antibody |
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abx440883-100ug | Abbexa | 100 ug | EUR 551 |
![]() DNA / RNA Damage Antibody |
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abx441164-100ug | Abbexa | 100 ug | EUR 551 |
![]() DNA / RNA Damage Antibody |
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abx441445-100ug | Abbexa | 100 ug | EUR 551 |
![]() DNA / RNA Damage Antibody |
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abx441726-100ug | Abbexa | 100 ug | EUR 551 |
![]() DNA / RNA Damage Antibody |
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abx442007-100ug | Abbexa | 100 ug | EUR 551 |
![]() DNA / RNA Damage Antibody |
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abx442288-100ug | Abbexa | 100 ug | EUR 551 |
![]() DNA / RNA Damage Antibody |
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abx442569-100ug | Abbexa | 100 ug | EUR 551 |
![]() DNA / RNA Damage Antibody |
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abx442850-100ug | Abbexa | 100 ug | EUR 551 |
![]() DNA / RNA Damage Antibody |
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abx443130-100ug | Abbexa | 100 ug | EUR 551 |
![]() DNA / RNA Damage Antibody |
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abx443410-100ug | Abbexa | 100 ug | EUR 537 |
![]() DNA / RNA Damage Antibody |
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abx443691-100ug | Abbexa | 100 ug | EUR 565 |
![]() DNA / RNA Damage Antibody |
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abx443972-100ug | Abbexa | 100 ug | EUR 551 |
![]() DNA / RNA Damage Antibody |
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abx444253-100ug | Abbexa | 100 ug | EUR 551 |
![]() DNA / RNA Damage Antibody |
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abx444534-100ug | Abbexa | 100 ug | EUR 551 |
![]() DNA / RNA Damage Antibody |
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20-abx444884 | Abbexa |
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![]() Genomic DNA from Rat Normal Tissue: Brain |
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D1434035 | Biochain | 100 ug | EUR 282 |
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
![]() EZCell? Cell Stimulation and Protein Transport Inhibitor Cocktail (500X) |
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K931-set | Biovision | EUR 370 |
![]() EZBlock? Universal Protease and Phosphatase Inhibitor Cocktail , EDTA-Free |
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K284-set | Biovision | EUR 626 |
![]() MAX LIFE Gene Analyzer - Fluorometer for DNA, RNA and Protein |
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H100 | GeneOn | 1 pcs | Ask for price |
![]() Human Kin17 DNA And RNA Binding Protein (KIN) ELISA Kit |
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abx388159-96tests | Abbexa | 96 tests | EUR 911 |
![]() ELISA Microplate Washer Automated (#MPW-30) bottle set (3 bottles and cap assembly) |
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MPW-30-SET | Alpha Diagnostics | 1 | EUR 408 |
![]() Total RNA from Rat Normal Tissue: Brain, cerebellum |
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R1434039-50 | Biochain | 50 ug | EUR 152 |
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
![]() NUCLEAZOR, DNA & RNA Decontaminant Spray |
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N5000-025 | GenDepot | 250 ml | EUR 135 |
![]() Total RNA from Alzheimer's Disease: Brain |
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R1236035Alz-50 | Biochain | 50 ug | EUR 351 |
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
![]() Human DNA-directed RNA polymerases I and III subunit RPAC2 (POLR1D) |
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1-CSB-EP897095HU | Cusabio |
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Description: Recombinant Human DNA-directed RNA polymerases I and III subunit RPAC2(POLR1D) expressed in E.coli |
![]() Human DNA-directed DNA/RNA polymerase mu (POLM) |
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1-CSB-EP889065HU | Cusabio |
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Description: Recombinant Human DNA-directed DNA/RNA polymerase mu(POLM) expressed in E.coli |
![]() Human DNA-directed DNA/RNA polymerase mu (POLM) |
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1-CSB-BP889065HU | Cusabio |
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Description: Recombinant Human DNA-directed DNA/RNA polymerase mu(POLM) expressed in Baculovirus |
![]() Human DNA-directed DNA/RNA polymerase mu (POLM) |
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1-CSB-YP889065HU | Cusabio |
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Description: Recombinant Human DNA-directed DNA/RNA polymerase mu(POLM) expressed in Yeast |
![]() Recombinant human DNA-directed DNA/RNA polymerase mu |
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P2815 | FN Test | 100ug | Ask for price |
Description: Recombinant protein for human DNA-directed DNA/RNA polymerase mu |
![]() StemBoost? YPAC Cocktail Set (1000X), Sterile-Filtered |
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K871-set | Biovision | EUR 958 |
![]() StemBoost? Reprogramming Cocktail Set I (1000X), Sterile-Filtered |
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K869-set | Biovision | EUR 849 |
![]() StemBoost? Reprogramming Cocktail Set II (1000X), Sterile-Filtered |
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K870-set | Biovision | EUR 838 |
![]() StemBoost? 2i-Reprogramming Cocktail Set (1000X), Sterile-Filtered |
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K889-set | Biovision | EUR 620 |
![]() Brain and Acute Leukemia, Cytoplamatic |
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PR27238 | Neuromics | 2 ug | EUR 191 |
![]() StemBoost? SMAD Signaling Inhibitor Cocktail Set (1000X), Sterile-Filtered |
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K877-set | Biovision | EUR 512 |
![]() StemBoost? Neuronal Cell Induction Cocktail Set (100X), Sterile-Filtered |
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K891-set | Biovision | EUR 805 |
![]() DNA-Directed RNA Polymerases I, II, And III Subunit RPABC1 (POLR2E) Antibody |
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20-abx304890 | Abbexa |
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![]() DNA-Directed RNA Polymerases I, II, And III Subunit RPABC4 (POLR2K) Antibody |
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20-abx304897 | Abbexa |
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![]() DNA-Directed RNA Polymerases I, II, And III Subunit RPABC3 (RPAB3) Antibody |
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20-abx149876 | Abbexa |
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![]() DNA-Directed RNA Polymerases I, II, And III Subunit RPABC1 (RPAB1) Antibody |
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20-abx119102 | Abbexa |
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![]() DNA-Directed RNA Polymerases I, II, And III Subunit RPABC1 (POLR2E) Antibody |
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20-abx121663 | Abbexa |
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![]() DNA-Directed RNA Polymerases I, II, And III Subunit RPABC4 (POLR2K) Antibody |
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20-abx135780 | Abbexa |
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![]() DNA-Directed RNA Polymerases I, II, And III Subunit RPABC1 (POLR2E) Antibody |
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20-abx114604 | Abbexa |
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![]() DNA-Directed RNA Polymerases I, II, And III Subunit RPABC1 (POLR2E) Antibody |
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abx036186-100ug | Abbexa | 100 ug | EUR 391 |
![]() DNA-Directed RNA Polymerases I, II, And III Subunit RPABC4 (POLR2K) Antibody |
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20-abx007835 | Abbexa |
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![]() DNA-Directed RNA Polymerases I, II, And III Subunit RPABC1 (POLR2E) Antibody |
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20-abx001458 | Abbexa |
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![]() DNA-Directed RNA Polymerases I, II, And III Subunit RPABC1 (POLR2E) Antibody |
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abx028042-400ul | Abbexa | 400 ul | EUR 523 |
![]() DNA-Directed RNA Polymerases I, II, And III Subunit RPABC1 (POLR2E) Antibody |
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abx028042-80l | Abbexa | 80 µl | EUR 286 |
![]() DNA-Directed RNA Polymerases I, II, And III Subunit RPABC2 (RPAB2) Antibody |
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20-abx217855 | Abbexa |
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![]() DNA-Directed RNA Polymerases I, II, And III Subunit RPABC4 (RPAB4) Antibody |
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20-abx217857 | Abbexa |
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![]() 96-well Viral DNA/RNA Kit |
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K1417-1 | Biovision | EUR 392 |
![]() 96-well Viral DNA/RNA Kit |
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K1417-4 | Biovision | EUR 1023 |
![]() ISOLATE II RNA/DNA/Protein Kit |
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BIO-52085 | Bioline | 50 preps | Ask for price |
![]() ISOLATE II RNA/DNA/Protein Kit |
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BIO-52085/S | Bioline | Sample | Ask for price |
![]() ISOLATE II FFPE RNA/DNA Kit |
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BIO-52087 | Bioline | 50 Preps | Ask for price |
![]() Monoclonal antibody for DNA/RNA Damage |
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SMC-155C | Stressmarq | 0.025mg | EUR 190 |
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Dog | Rabbit DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is not conjugated. |
![]() Monoclonal antibody for DNA/RNA Damage |
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SMC-155D | Stressmarq | 0.1mg | EUR 332 |
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Dog | Rabbit DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is not conjugated. |
![]() Monoclonal antibody for DNA/RNA Damage |
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SMC-155D-A390 | Stressmarq | 0.1mg | EUR 379 |
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Dog | Rabbit DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 390. |
![]() Monoclonal antibody for DNA/RNA Damage |
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SMC-155D-A488 | Stressmarq | 0.1mg | EUR 378 |
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 488. |
![]() Monoclonal antibody for DNA/RNA Damage |
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SMC-155D-A565 | Stressmarq | 0.1mg | EUR 378 |
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 565. |
![]() Monoclonal antibody for DNA/RNA Damage |
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SMC-155D-A594 | Stressmarq | 0.1mg | EUR 378 |
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 594. |
![]() Monoclonal antibody for DNA/RNA Damage |
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SMC-155D-A633 | Stressmarq | 0.1mg | EUR 378 |
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 633. |
![]() Monoclonal antibody for DNA/RNA Damage |
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SMC-155D-A655 | Stressmarq | 0.1mg | EUR 378 |
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 655. |
![]() Monoclonal antibody for DNA/RNA Damage |
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SMC-155D-A680 | Stressmarq | 0.1mg | EUR 378 |
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 680. |
![]() Monoclonal antibody for DNA/RNA Damage |
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SMC-155D-A700 | Stressmarq | 0.1mg | EUR 378 |
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 700. |
![]() Monoclonal antibody for DNA/RNA Damage |
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SMC-155D-ALP | Stressmarq | 0.1mg | EUR 372 |
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Alkaline Phosphatase. |
![]() Monoclonal antibody for DNA/RNA Damage |
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SMC-155D-APC | Stressmarq | 0.1mg | EUR 377 |
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with APC. |
![]() Monoclonal antibody for DNA/RNA Damage |
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SMC-155D-APCCY7 | Stressmarq | 0.1mg | EUR 450 |
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with APC/Cy7. |
![]() Monoclonal antibody for DNA/RNA Damage |
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SMC-155D-BI | Stressmarq | 0.1mg | EUR 374 |
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Biotin. |
![]() Monoclonal antibody for DNA/RNA Damage |
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SMC-155D-DY350 | Stressmarq | 0.1mg | EUR 393 |
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 350. |
![]() Monoclonal antibody for DNA/RNA Damage |
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SMC-155D-DY405 | Stressmarq | 0.1mg | EUR 381 |
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 405. |
![]() Monoclonal antibody for DNA/RNA Damage |
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SMC-155D-DY488 | Stressmarq | 0.1mg | EUR 371 |
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 488. |
![]() Monoclonal antibody for DNA/RNA Damage |
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SMC-155D-DY594 | Stressmarq | 0.1mg | EUR 373 |
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 594. |
![]() Monoclonal antibody for DNA/RNA Damage |
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SMC-155D-DY633 | Stressmarq | 0.1mg | EUR 368 |
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 633. |
![]() Monoclonal antibody for DNA/RNA Damage |
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SMC-155D-FITC | Stressmarq | 0.1mg | EUR 370 |
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with FITC. |
![]() Monoclonal antibody for DNA/RNA Damage |
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SMC-155D-HRP | Stressmarq | 0.1mg | EUR 366 |
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with HRP. |
![]() Monoclonal antibody for DNA/RNA Damage |
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SMC-155D-P594 | Stressmarq | 0.1mg | EUR 385 |
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with PE/ATTO 594. |
![]() Monoclonal antibody for DNA/RNA Damage |
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SMC-155D-PCP | Stressmarq | 0.1mg | EUR 377 |
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with PerCP. |
![]() Monoclonal antibody for DNA/RNA Damage |
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SMC-155D-RPE | Stressmarq | 0.1mg | EUR 375 |
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with RPE. |
![]() Monoclonal antibody for DNA/RNA Damage |
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SMC-155D-STR | Stressmarq | 0.1mg | EUR 376 |
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Streptavidin. |
![]() Monoclonal antibody for DNA/RNA Damage |
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SMC-155S | Stressmarq | 0.012mg | EUR 65 |
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is not conjugated. |
![]() Total RNA from Mouse Normal Tissue: Brain |
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R1334035-50 | Biochain | 50 ug | EUR 152 |
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
![]() ELISA kit for Rat DNA-directed RNA polymerases I, II, and III subunit RPABC1 (POLR2E) |
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KTE100871-48T | Abbkine | 48T | EUR 332 |
Description: Quantitative sandwich ELISA for measuring Rat DNA-directed RNA polymerases I, II, and III subunit RPABC1 (POLR2E) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
![]() ELISA kit for Rat DNA-directed RNA polymerases I, II, and III subunit RPABC1 (POLR2E) |
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KTE100871-5platesof96wells | Abbkine | 5 plates of 96 wells | EUR 2115 |
Description: Quantitative sandwich ELISA for measuring Rat DNA-directed RNA polymerases I, II, and III subunit RPABC1 (POLR2E) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
![]() ELISA kit for Rat DNA-directed RNA polymerases I, II, and III subunit RPABC1 (POLR2E) |
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KTE100871-96T | Abbkine | 96T | EUR 539 |
Description: Quantitative sandwich ELISA for measuring Rat DNA-directed RNA polymerases I, II, and III subunit RPABC1 (POLR2E) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
The 1982 revised criteria for the classification of systemic lupus erythematosus
The 1971 preliminary criteria for the classification of systemic lupus erythematosus (SLE) were revised and updated to incorporate new immunologic knowledge and improve disease classification. The 1982 revised criteria include fluorescence antinuclear antibody and antibody to native DNA and Sm antigen. Some criteria involving the same organ systems were aggregated into single criteria.
Raynaud’s phenomenon and alopecia were not included in the 1982 revised criteria because of low sensitivity and specificity. The new criteria were 96% sensitive and 96% specific when tested with SLE and control patient data gathered from 18 participating clinics. When compared with the 1971 criteria, the 1982 revised criteria showed gains in sensitivity and specificity.