nordiag

Integrated genomic analyses of ovarian carcinoma

Integrated genomic analyses of ovarian carcinoma A catalogue of molecular aberrations that cause ovarian cancer is critical for developing and deploying therapies that will improve patients’ lives. The Cancer Genome Atlas project has analysed messenger RNA expression, microRNA expression, promoter methylation and DNA copy number in 489 high-grade serous ovarian adenocarcinomas and the DNA sequences of exons from coding […]

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nordiag

A framework for variation discovery and genotyping using next-generation DNA sequencing data.

A framework for variation discovery and genotyping using next-generation DNA sequencing data. Recent advances in sequencing technology make it possible to comprehensively catalog genetic variation in population samples, creating a foundation for understanding human disease, ancestry and evolution. The amounts of raw data produced are prodigious, and many computational steps are required to translate this output into […]

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