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GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research–an update.

  June 20, 2021
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GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research–an update. GenAlEx: Genetic Analysis in Excel is a cross-platform package for population genetic analyses that runs within Microsoft Excel. GenAlEx offers analysis of diploid codominant, haploid and binary genetic loci and DNA sequences. Both frequency-based (F-statistics, heterozygosity, HWE, population assignment, relatedness) and distance-based (AMOVA, […]

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A haplotype map of the human genome.

  May 27, 2021
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A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems provide bacteria and archaea with adaptive immunity against viruses and plasmids by using CRISPR RNAs (crRNAs) to guide the silencing of invading nucleic acids. We show here that in a subset of these systems, the mature crRNA that is […]

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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

  May 25, 2021
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Comprehensive genomic characterization defines human glioblastoma genes and core pathways Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide substitutions and epigenetic modifications that drive malignant transformation. The Cancer Genome Atlas (TCGA) pilot project aims to assess the value of large-scale multi-dimensional analysis of these molecular characteristics in human cancer and to provide the data […]

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MEME SUITE: tools for motif discovery and searching.

  April 28, 2021
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A bivalent chromatin structure marks key developmental genes in embryonic stem cells The most highly conserved noncoding elements (HCNEs) in mammalian genomes cluster within regions enriched for genes encoding developmentally important transcription factors (TFs). This suggests that HCNE-rich regions may contain key regulatory controls involved in development. We explored this by examining histone methylation in […]

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Integrated genomic analyses of ovarian carcinoma

 
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Integrated genomic analyses of ovarian carcinoma A catalogue of molecular aberrations that cause ovarian cancer is critical for developing and deploying therapies that will improve patients’ lives. The Cancer Genome Atlas project has analysed messenger RNA expression, microRNA expression, promoter methylation and DNA copy number in 489 high-grade serous ovarian adenocarcinomas and the DNA sequences of exons from coding […]

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Evolution of Quality Assurance for Clinical Immunohistochemistry

  April 13, 2021
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This is a novel and affordable solution to all major problems with immunohistochemistry on paraffin sections. Ease of use combined with high reproducibility of the results will give you the best quality immunostaining Run antigen unmasking in 6 various buffers at once Perform gentle antigen retrieval that does not damage the tissue morphology Get identical results every time Sections […]

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A framework for variation discovery and genotyping using next-generation DNA sequencing data.

 
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A framework for variation discovery and genotyping using next-generation DNA sequencing data. Recent advances in sequencing technology make it possible to comprehensively catalog genetic variation in population samples, creating a foundation for understanding human disease, ancestry and evolution. The amounts of raw data produced are prodigious, and many computational steps are required to translate this output into […]

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Cancer PCR studies

 
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Approximately 50 % of all men and a third of all women develop cancer during their lifetime. The best way to beat cancer is by detecting it early, while it is still confined to the organ of origin and consequently has the best prognosis for successful treatment. There is a need for tests that contribute […]

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DNA purification

 
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Load the primary tubes and reagents and walk away! 96 samples from primary tubes to PCR set-up in approximately 2 hours  Automated barcode reading Minimal manual handling No centrifugation BUGS´n BEADS™ MRSA from Genpoint-NorDiag is an easy-to-perform, automated method for isolation of DNA from Staphylococcus aureus. The kit has successfully been used for isolation of DNA from MRSA […]

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TB (Tuberculosis)

 
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BUGS´n BEADS™ TB from Genpoint-NorDiag is an easy-to-perform and automated method for isolation of DNA and RNA from bacteria. The kit has successfully been used for  the isolation of Mycobacterium Tuberculosis present in sputum as well as other non respiratory samples, and can be combined with various downstream detection systems such as PCR*, Strand Displacement Amplification (SDA**) […]

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