Uncompromising EV insulation delivers higher yields and cleaner setups Leveraging our years of exosome experience, the SBI team has propelled ExoQuick-TC extracellular vesicle (EV) isolation technology to new performance peaks with ExoQuick-TC ULTRA for tissue culture media and most biofluids. While many EV insulation methods force you to choose between high yields, simple protocols, clean […]
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Pfizer and BioNTech’s corona vaccine is one step further towards approval for emergency use in the United States. The FDA has released a report on the vaccine. This shows that the vaccine does indeed work well and is safe. Together with the report on the UK approval, this provides a lot of new information. The British regulator MHRA […]
Read MoreThe protein kinase complement of the human genome. We have catalogued the protein kinase complement of the human genome (the “kinome”) using public and proprietary genomic, complementary DNA, and expressed sequence tag (EST) sequences. This provides a starting point for comprehensive analysis of protein phosphorylation in normal and disease states, as well as a detailed view […]
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GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research–an update. GenAlEx: Genetic Analysis in Excel is a cross-platform package for population genetic analyses that runs within Microsoft Excel. GenAlEx offers analysis of diploid codominant, haploid and binary genetic loci and DNA sequences. Both frequency-based (F-statistics, heterozygosity, HWE, population assignment, relatedness) and distance-based (AMOVA, […]
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A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems provide bacteria and archaea with adaptive immunity against viruses and plasmids by using CRISPR RNAs (crRNAs) to guide the silencing of invading nucleic acids. We show here that in a subset of these systems, the mature crRNA that is […]
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Comprehensive genomic characterization defines human glioblastoma genes and core pathways Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide substitutions and epigenetic modifications that drive malignant transformation. The Cancer Genome Atlas (TCGA) pilot project aims to assess the value of large-scale multi-dimensional analysis of these molecular characteristics in human cancer and to provide the data […]
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A bivalent chromatin structure marks key developmental genes in embryonic stem cells The most highly conserved noncoding elements (HCNEs) in mammalian genomes cluster within regions enriched for genes encoding developmentally important transcription factors (TFs). This suggests that HCNE-rich regions may contain key regulatory controls involved in development. We explored this by examining histone methylation in […]
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Integrated genomic analyses of ovarian carcinoma A catalogue of molecular aberrations that cause ovarian cancer is critical for developing and deploying therapies that will improve patients’ lives. The Cancer Genome Atlas project has analysed messenger RNA expression, microRNA expression, promoter methylation and DNA copy number in 489 high-grade serous ovarian adenocarcinomas and the DNA sequences of exons from coding […]
Read MoreThis is a novel and affordable solution to all major problems with immunohistochemistry on paraffin sections. Ease of use combined with high reproducibility of the results will give you the best quality immunostaining Run antigen unmasking in 6 various buffers at once Perform gentle antigen retrieval that does not damage the tissue morphology Get identical results every time Sections […]
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A framework for variation discovery and genotyping using next-generation DNA sequencing data. Recent advances in sequencing technology make it possible to comprehensively catalog genetic variation in population samples, creating a foundation for understanding human disease, ancestry and evolution. The amounts of raw data produced are prodigious, and many computational steps are required to translate this output into […]
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